NCT00486200

Brief Summary

A study of ASP2151 in subjects with recurrent outbreaks of genital herpes.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
695

participants targeted

Target at P75+ for phase_2

Timeline
Completed

Started Jun 2007

Shorter than P25 for phase_2

Geographic Reach
1 country

25 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 12, 2007

Completed
2 days until next milestone

First Posted

Study publicly available on registry

June 14, 2007

Completed
7 days until next milestone

Study Start

First participant enrolled

June 21, 2007

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 12, 2008

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 12, 2008

Completed
Last Updated

December 7, 2017

Status Verified

December 1, 2017

Enrollment Period

1.1 years

First QC Date

June 12, 2007

Last Update Submit

December 1, 2017

Conditions

Keywords

ASP2151Herpes GenitalisSexually Transmitted DiseaseHerpes Simplex Virus Genital InfectionTreatment OutcomeGenital Herpes

Outcome Measures

Primary Outcomes (1)

  • To compare the efficacy and safety of ASP2151 with valacyclovir and placebo in the acute treatment of recurrent genital Herpes Simplex Virus Infection

    17 days

Secondary Outcomes (1)

  • Pharmacokinetics in study patients

    4 days

Study Arms (6)

1

ACTIVE COMPARATOR

Oral administration of active comparator

Drug: valacyclovir

2

PLACEBO COMPARATOR

Oral administration of placebo

Drug: Placebo

3

EXPERIMENTAL

Dosing regimen 1

Drug: ASP2151

4

EXPERIMENTAL

Dosing regimen 2

Drug: ASP2151

5

EXPERIMENTAL

Dosing regimen 3

Drug: ASP2151

6

EXPERIMENTAL

Dosing regimen 4

Drug: ASP2151

Interventions

Oral administration.

3456

Oral administration of active comparator.

1

Oral administration of placebo.

2

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Subject has a history of genital HSV documented by laboratory testing at screening
  • Subject has experienced 4 or more episodes of genital herpes during the past 12 months

You may not qualify if:

  • Subject is immunocompromised

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (25)

Unknown Facility

Birmingham, Alabama, 35294, United States

Location

Unknown Facility

Phoenix, Arizona, 85015, United States

Location

Unknown Facility

Tucson, Arizona, 85712, United States

Location

Unknown Facility

Los Angeles, California, 90017, United States

Location

Unknown Facility

Sacramento, California, 95821, United States

Location

Unknown Facility

San Diego, California, 92108, United States

Location

Unknown Facility

Westlake Village, California, 91361, United States

Location

Unknown Facility

Denver, Colorado, 80262, United States

Location

Unknown Facility

Boynton Beach, Florida, 33472, United States

Location

Unknown Facility

Miami, Florida, 33156, United States

Location

Unknown Facility

Atlanta, Georgia, 30328, United States

Location

Unknown Facility

Indianapolis, Indiana, 46202, United States

Location

Unknown Facility

Madisonville, Kentucky, 42431, United States

Location

Unknown Facility

Baltimore, Maryland, 21201, United States

Location

Unknown Facility

Billings, Montana, 59101, United States

Location

Unknown Facility

Omaha, Nebraska, 68134, United States

Location

Unknown Facility

Albuquerque, New Mexico, 87131, United States

Location

Unknown Facility

Portland, Oregon, 97210, United States

Location

Unknown Facility

Philadelphia, Pennsylvania, 19103, United States

Location

Unknown Facility

Arlington, Texas, 76011, United States

Location

Unknown Facility

Houston, Texas, 77030, United States

Location

Unknown Facility

Houston, Texas, 77058, United States

Location

Unknown Facility

Salt Lake City, Utah, 84132, United States

Location

Unknown Facility

Annandale, Virginia, 22003, United States

Location

Unknown Facility

Seattle, Washington, 98122, United States

Location

Related Publications (1)

  • Tyring S, Wald A, Zadeikis N, Dhadda S, Takenouchi K, Rorig R. ASP2151 for the treatment of genital herpes: a randomized, double-blind, placebo- and valacyclovir-controlled, dose-finding study. J Infect Dis. 2012 Apr 1;205(7):1100-10. doi: 10.1093/infdis/jis019. Epub 2012 Feb 20.

    PMID: 22351940BACKGROUND

Related Links

MeSH Terms

Conditions

Herpes GenitalisSexually Transmitted Diseases

Interventions

ASP2151Valacyclovir

Condition Hierarchy (Ancestors)

Sexually Transmitted Diseases, ViralCommunicable DiseasesInfectionsHerpes SimplexHerpesviridae InfectionsDNA Virus InfectionsVirus DiseasesGenital Diseases, FemaleFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesGenital DiseasesGenital Diseases, MaleMale Urogenital DiseasesDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

AcyclovirGuanineHypoxanthinesPurinonesPurinesHeterocyclic Compounds, 2-RingHeterocyclic Compounds, Fused-RingHeterocyclic Compounds

Study Officials

  • Use Central Contact

    Astellas Pharma US, Inc.

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 12, 2007

First Posted

June 14, 2007

Study Start

June 21, 2007

Primary Completion

August 12, 2008

Study Completion

August 12, 2008

Last Updated

December 7, 2017

Record last verified: 2017-12

Locations