Thrombophilia and Thyroid Autoimmunity in Implantation Failure and Recurrent Miscarriage

NCT00485446 | Completed

• 1 other identifier: VLC-JB-0304-307-10
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

This study was designed to evaluate the incidence of both, inherited and adquired thrombophilia, and thyroid autoinmunity in unknown infertility (UI), implantation failure (IF) and recurrent miscarriage (RM). To focus on these particular disorders and to rule out another potential confounding variables, 4 particular groups of women were created. Only young women (\< 38 years old), patients whose previous preimplantation genetic screening (PGS) cycles displayed an acceptable rate of aneploidies, and women without organic uterine abnormality, autoimmune disease or endocrine disorder were included in the study.

Conditions

Thrombophilia, Thyroid Autoimmunity

Interventions

blood analysis PROCEDURE

Eligibility Criteria

• Age: 18 Years - 37 Years
• Sex: female
• Age Groups: Adult (18-64)

You may qualify if:

• The control group included 32 oocyte donors, 18-35 years old, white caucasian, with normal karyotype, no miscarriages, and previous healthy live born infants without pregnancy complications.
• The UI group consisted of 31 couples with \> 1 year infertility , \< 38 years of age, normal ovarian function, normal hysterosalpingography and transvaginal ultrasound scan of the uterus and ovaries, normal karyotype in both parents, and normozoospermia.
• The IF group included 26 couples with 3.9±1.1 IVF failures with embryo transfer of at least 2 good quality embryos. They were \< 38 years old, white caucasian, and had normal uterus by vaginal ultrasound and/or hysterosalpingography/ hysteroscopy. Moreover, endocrine disorders or autoimmune diseases were ruled out, a normal karyotype was found in both parents. The male had a sperm concentration \> 5 mill/ml.They also had a PGS cycle with ≥ 60% of normal embryos.
• The group of women with RM (n = 30) had 3.2±1.3 (range: 2-9) previous miscarriages. They were \< 38 years old, white caucasian, with normal uterus by vaginal ultrasound and/or hysterosalpingography/ hysteroscopy. Also, no endocrine anomalies or autoimmune diseases were found, and both parents had normal karyotype. Sperm concentration was \> 5 mill/ml. Only 6 women had 2 miscarriages (20%) and the remaining 24 women at least 3. They also had a PGS cycle with ≥ 60% of normal embryos.

Sponsors & Collaborators

• Instituto Valenciano de Infertilidad, IVI VALENCIA: lead

Study Sites (1)

Ivi Valencia

Valencia, Valencia, 46015, Spain

Location

MeSH Terms

Conditions

Thrombophilia

Interventions

Hematologic Tests

Condition Hierarchy (Ancestors)

Hematologic Diseases; Hemic and Lymphatic Diseases

Intervention Hierarchy (Ancestors)

Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques

Study Officials

• Jose Bellver, MD

  IVI Valencia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: DEFINED POPULATION
• Time Perspective: OTHER
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: June 12, 2007
• First Posted: June 13, 2007
• Last Updated: June 13, 2007

Record last verified: 2007-06

Locations

ES (1)