NCT00485147

Brief Summary

The maximal walking distance (MWD) performed on treadmill (TT) remains the gold standard in estimating the walking capacity of patients suffering from peripheral arterial disease (PAD) with intermittent claudication, although treadmills are not accessible to most physicians. We hypothesized that global positioning system (GPS) recordings could monitor community-based outdoor walking and provide valid information on walking capacity in PAD patients.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
140

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Mar 2006

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2006

Completed
1.3 years until next milestone

First Submitted

Initial submission to the registry

June 11, 2007

Completed
1 day until next milestone

First Posted

Study publicly available on registry

June 12, 2007

Completed
3.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2010

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2010

Completed
Last Updated

July 2, 2012

Status Verified

April 1, 2010

Enrollment Period

4.8 years

First QC Date

June 11, 2007

Last Update Submit

June 28, 2012

Conditions

Keywords

Claudicationperipheral arterial diseaseDiagnosisExerciseWalking impairmentDisability

Outcome Measures

Primary Outcomes (2)

  • Validate the ability of GPS to detect walking and resting bouts and to accurately estimate walking speed and distance in normal subjects.

    2 years

  • Measurement of maximal walking distance using GPS and comparison with treadmill measurement in PAD patients.

    2 years

Secondary Outcomes (3)

  • Determine the variability of the walking capacity and its potential determinants in PAD patients.

    3 years

  • Analyse the reliability and sensibility of GPS measurements of the walking capacity in PAD patients.

    4 years

  • Analyse potential factors that could affect the accuracy of GPS measurements

    4 years

Interventions

Analyse the clinical change after surgery from GPS measurements and compare it with laboratory measurement.

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Ankle to Brachial Index (ABI) \< 0.95 for PAD patients
  • Age \> 18 years old
  • Able to walk on treadmill

You may not qualify if:

  • limb pain of potential non-vascular origin
  • myocardial infraction in the last six months
  • uncontrolled angina pectoris

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Centre hospitalier universitaire

Angers, 49933, France

Location

Related Publications (2)

  • Noury-Desvaux B, Abraham P, Mahe G, Sauvaget T, Leftheriotis G, Le Faucheur A. The accuracy of a simple, low-cost GPS data logger/receiver to study outdoor human walking in view of health and clinical studies. PLoS One. 2011;6(9):e23027. doi: 10.1371/journal.pone.0023027. Epub 2011 Sep 13.

  • Le Faucheur A, Noury-Desvaux B, Mahe G, Sauvaget T, Saumet JL, Leftheriotis G, Abraham P. Variability and short-term determinants of walking capacity in patients with intermittent claudication. J Vasc Surg. 2010 Apr;51(4):886-92. doi: 10.1016/j.jvs.2009.10.120.

MeSH Terms

Conditions

Peripheral Arterial DiseaseIntermittent ClaudicationDiseaseMotor Activity

Condition Hierarchy (Ancestors)

AtherosclerosisArteriosclerosisArterial Occlusive DiseasesVascular DiseasesCardiovascular DiseasesPeripheral Vascular DiseasesSigns and SymptomsPathological Conditions, Signs and SymptomsPathologic ProcessesBehavior

Study Officials

  • Pierre Abraham, MD, PhD

    Laboratory for Vascular Investigations. University Hospital. Angers. France.

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
DIAGNOSTIC
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER GOV
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 11, 2007

First Posted

June 12, 2007

Study Start

March 1, 2006

Primary Completion

December 1, 2010

Study Completion

December 1, 2010

Last Updated

July 2, 2012

Record last verified: 2010-04

Locations