Study of Sperm Molecular Factors Implicated in Male Fertility
Microarray Analysis in Sperm From Fertile and Infertile Males Without Basic Sperm Analysis Abnormalities
1 other identifier
observational
100
1 country
1
Brief Summary
Sperm analysis following World Health Organization guidelines is unable to explain the molecular causes of male infertility when basic sperm parameters are within a normal range and women do not present gynaecological pathology. Subsequently, there is a need for accurate diagnostic tools in this sense and microarray technology applied to sperm analysis emerges as a promising field
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started May 2006
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2006
CompletedFirst Submitted
Initial submission to the registry
May 31, 2007
CompletedFirst Posted
Study publicly available on registry
June 1, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2016
CompletedApril 1, 2022
March 1, 2022
10.6 years
May 31, 2007
March 31, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Sperm mRNAs expression profile in samples achieving pregnancy vs those who failed in different assisted reproduction techniques
10 months
Interventions
Microarray analysis
Microarray
Eligibility Criteria
Infertile male undergoing assisted reproduction technique without abnormal sperm parameters described by the OMS. Female partners are under 37 years old, IBM lower than 30 kg/m2 and do not present any obvious infertility problem as fallopian tubal obstruction, endometriosis, ovarian failure or polycystic ovarian syndrome.
You may qualify if:
- Fertile (controls) or infertile males, with sperm parameters above the WHO criteria values
You may not qualify if:
- Well established infertility causes
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Instituto Universitario Ivi
Valencia, 46015, Spain
Related Publications (1)
1. Garrido N, Meseguer M, Alvarez J, Simon C, Pellicer A, Remohi J. Relationship among standard semen parameters, glutathione peroxidase/glutathione reductase activity, and mRNA expression and reduced glutathione content in ejaculated spermatozoa from fertile and infertile men. Fertil Steril. 2004 Oct;82 Suppl 3:1059-66. 2. Krawetz SA. Paternal contribution: New insights and future challenges. Nat Rev Genet. 2005;6:633-42. 3. Kramer JA, Krawetz SA. RNA in spermatozoa: Implications for the alternative haploid genome. Mol Hum Reprod. 1997;3:473-8. 4. Wykes SM, Visscher DW, Krawetz SA. Haploid transcripts persist in mature human spermatozoa. Mol Hum Reprod. 1997; 3:15-9.
BACKGROUND
Biospecimen
After sperm washing, sperm pellet was suspended in trizol and immediately frozen by direct immersion in liquid nitrogen and stored in a nitrogen tank until mRNA extraction.
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Nicolas Garrido, PhD
Instituto Universitario IVI
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Director of Andrology IVI Valencia
Study Record Dates
First Submitted
May 31, 2007
First Posted
June 1, 2007
Study Start
May 1, 2006
Primary Completion
December 1, 2016
Study Completion
December 1, 2016
Last Updated
April 1, 2022
Record last verified: 2022-03