NCT00478894

Brief Summary

In this study we will examine patients who have undergone unilateral ACL reconstruction surgery to determine which structural and functional characteristics of the knee two and ten years post reconstruction surgery, aspects of the original injury and repair, and patient characteristics are risk factors for osteoarthritis after ACL reconstruction surgery.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
432

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Aug 2007

Longer than P75 for all trials

Geographic Reach
1 country

4 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 24, 2007

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 25, 2007

Completed
2 months until next milestone

Study Start

First participant enrolled

August 1, 2007

Completed
18.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2025

Completed
Last Updated

January 27, 2026

Status Verified

January 1, 2026

Enrollment Period

18.3 years

First QC Date

May 24, 2007

Last Update Submit

January 25, 2026

Conditions

Rupture of Anterior Cruciate LigamentOsteoarthritis

Keywords

Anterior cruciate ligament / injuriesAnterior cruciate ligament / surgeryknee injuries / surgeryoutcomes researchprospective studiesosteoarthritis

Outcome Measures

Primary Outcomes (1)

  • Side to side knee joint space difference as seen on x-ray

    2-20 years post surgery

Eligibility Criteria

Age14 Years - 55 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)
Sampling MethodNon-Probability Sample
Study Population

Participants enrolled in the Multicenter Orthopaedic Outcomes Network cohort by one of three surgeons and meeting eligibility criteria

You may qualify if:

  • Had primary unilateral ACL reconstruction performed by Dr. Kurt Spindler (Vanderbilt University), Dr. Christopher Kaeding (The Ohio State University), Dr. Rick Parker (Cleveland Clinic), Dr. Jack Andrish (Cleveland Clinic), Dr. Rick Wright (Washington University in St. Louis), or Dr. Matthew Matava (Washington University in St. Louis)
  • years of age at the time of follow-up

You may not qualify if:

  • less than 14 years or greater than 55 years
  • non-active or unable to participate for health reasons

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (4)

Washington University in St. Louis

St Louis, Missouri, 63110, United States

Location

Cleveland Clinic

Cleveland, Ohio, 44195, United States

Location

The Ohio State University

Columbus, Ohio, 43221, United States

Location

Vanderbilt University

Nashville, Tennessee, 37232, United States

Location

Related Publications (3)

  • Reinke EK, Spindler KP, Lorring D, Jones MH, Schmitz L, Flanigan DC, An AQ, Quiram AR, Preston E, Martin M, Schroeder B, Parker RD, Kaeding CC, Borzi L, Pedroza A, Huston LJ, Harrell FE Jr, Dunn WR. Hop tests correlate with IKDC and KOOS at minimum of 2 years after primary ACL reconstruction. Knee Surg Sports Traumatol Arthrosc. 2011 Nov;19(11):1806-16. doi: 10.1007/s00167-011-1473-5. Epub 2011 Mar 29.

    PMID: 21445595RESULT

  • Ramkumar PN, Tariq MB; MOON Knee Group; Amendola A, Andrish JT, Brophy RH, Dunn WR, Flanigan DC, Huston LJ, Jones MH, Kaeding CC, Kattan MW, Marx RG, Matava MJ, McCarty EC, Parker RD, Vidal AF, Wolcott ML, Wolf BR, Wright RW, Spindler KP. Risk Factors for Loss to Follow-up in 3202 Patients at 2 Years After Anterior Cruciate Ligament Reconstruction: Implications for Identifying Health Disparities in the MOON Prospective Cohort Study. Am J Sports Med. 2019 Nov;47(13):3173-3180. doi: 10.1177/0363546519876925. Epub 2019 Oct 7.

    PMID: 31589465DERIVED

  • Jacobs CA, Peabody MR, Lattermann C, Vega JF, Huston LJ, Spindler KP; MOON Knee Group; Amendola A, Andrish JT, Brophy RH, Dunn WR, Flanigan DC, Jones MH, Kaeding CC, Marx RG, Matava MJ, McCarty EC, Parker RD, Reinke EK, Wolcott ML, Wolf BR, Wright RW, Vidal AF. Development of the KOOSglobal Platform to Measure Patient-Reported Outcomes After Anterior Cruciate Ligament Reconstruction. Am J Sports Med. 2018 Oct;46(12):2915-2921. doi: 10.1177/0363546518789619. Epub 2018 Aug 3.

    PMID: 30074823DERIVED

MeSH Terms

Conditions

Anterior Cruciate Ligament InjuriesOsteoarthritisKnee Injuries

Condition Hierarchy (Ancestors)

Leg InjuriesWounds and InjuriesArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic Diseases

Study Officials

  • Kurt P Spindler, M.D.

    Cleveland Clinic / Vanderbilt University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

May 24, 2007

First Posted

May 25, 2007

Study Start

August 1, 2007

Primary Completion

December 1, 2025

Study Completion

December 1, 2025

Last Updated

January 27, 2026

Record last verified: 2026-01

Locations

US(4)