NCT00476450|Completed
Effects of Stem Cell Transplantation on Bacteria in the Mouth
Effects of Peripheral Blood Stem Cell Transplantation on the Microbial Flora of the Oral Cavity
Loading search results
Effects of Peripheral Blood Stem Cell Transplantation on the Microbial Flora of the Oral Cavity
Sponsor study identifier
Secondary identifiers
observational
50
1 country
1
Study Start
May 16, 2007
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
March 7, 2016
Date type not reportedThis date has not been verified as actual or estimated.
This study will examine bacteria in patients mouths at different times during stem cell transplantation and recovery. Drugs patients receive as part of the conditioning process for a stem cell transplant increase their risk of infection. There might be a link between the bacteria in the mouth and the bacteria that can cause infections. Knowing the changes in bacteria might help researchers determine the best method to prevent infections. Patients 18 years of age and older who are scheduled to receive a stem cell transplant may be eligible for this study. Participants undergo the following procedures: Review of medical records Interview about their oral care Oral examination Collection of oral specimens just before the stem cell transplant, immediately after the transplant, and 3 weeks after the transplant. The specimens are obtained as follows:
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
March 7, 2016
Date type not reportedThis date has not been verified as actual or estimated.
Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 16, 2007
Date type not reportedThis date has not been verified as actual or estimated.
May 19, 2007
Actual (reported)May 22, 2007
Actual (reported)March 7, 2016
Date type not reportedThis date has not been verified as actual or estimated.
Description of the oral microbiome
Baseline, nadir of ANC and engraftment.
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, 20892, United States
Socransky SS, Haffajee AD. Periodontal microbial ecology. Periodontol 2000. 2005;38:135-87. doi: 10.1111/j.1600-0757.2005.00107.x. No abstract available.
Mager DL, Ximenez-Fyvie LA, Haffajee AD, Socransky SS. Distribution of selected bacterial species on intraoral surfaces. J Clin Periodontol. 2003 Jul;30(7):644-54. doi: 10.1034/j.1600-051x.2003.00376.x.
Kolenbrander PE, Andersen RN, Blehert DS, Egland PG, Foster JS, Palmer RJ Jr. Communication among oral bacteria. Microbiol Mol Biol Rev. 2002 Sep;66(3):486-505, table of contents. doi: 10.1128/MMBR.66.3.486-505.2002.
Nancy Ames, R.N.
National Institutes of Health Clinical Center (CC)
50 participants (actual enrollment reported by the registry).
First Submitted
May 19, 2007
First Posted
May 22, 2007
Study Start
May 16, 2007
Date type not reportedThis date has not been verified as actual or estimated.
Contact the study team to confirm eligibility.
Study Completion
March 7, 2016
Date type not reportedThis date has not been verified as actual or estimated.
Last Updated
October 6, 2017
Record last verified: 2016-03-07
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: