Aerobic Capacity and Body Composition in Colon Cancer Patients

NCT00470782 | Completed DMC

• 1 other identifier: GI-5-0064 / ethics 23429
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Recent studies have shown that survival after a colorectal cancer diagnosis may be affected by a person's activity level and body size. This research says that for colorectal cancer patients, the less active and more obese they are, the more likely they are to have a cancer recurrence or die from their cancer. Chemotherapy has been shown to reduce activity levels, fitness, and body size in some cancer patients. However, it is not known how chemotherapy specific for colon cancer patients affects their activity levels, fitness, and body size. The main goal of our study will be to look at how chemotherapy treatments affect the fitness, activity levels, and body size in colon cancer patients. In order to do this, we will measure these variables before chemotherapy treatments, and at 1 and 6 months following the end of treatment. Our results will show how chemotherapy affects fitness, activity levels, and body size in colon cancer patients and provide data to help in designing an exercise intervention specifically for colon cancer survivors.

Conditions

Colonic Neoplasms

Keywords

colonic neoplasms; exercise; body composition; anthropometry

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

community sample

You may qualify if:

• histologically confirmed colon cancer (Stage III and those Stage II patients deemed high-risk
• approval of the treating oncologist
• scheduled to received chemotherapy
• able to understand and provide written informed consent in English
• + years of age
• no uncontrolled co-morbidities (including hypertension, cardiac illness, psychiatric condition, etc.)
• negative ECG as assessed during maximal graded exercise test

You may not qualify if:

• metastatic or recurrent colon cancer patients
• pregnancy
• any uncontrolled medical condition that would be a contraindication to exercise (assessed by treating oncologist)
• unwilling to attend, travel to or participate in the assessments at all 3 time points
• In addition, 10 patients meeting all of the eligibility criteria who are not scheduled to receive chemotherapy will also be recruited to the study to serve as "surgery only" controls.

Sponsors & Collaborators

• AHS Cancer Control Alberta: lead

Study Sites (1)

Cross Cancer Institute

Edmonton, Alberta, T6G 1Z2, Canada

Location

MeSH Terms

Conditions

Colonic Neoplasms; Motor Activity

Condition Hierarchy (Ancestors)

Colorectal Neoplasms; Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Behavior

Study Officials

• Kerry Courneya, PhD

  University of Alberta

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 7, 2007
• First Posted: May 8, 2007
• Study Start: October 1, 2007
• Primary Completion: October 1, 2009
• Study Completion: October 1, 2009
• Last Updated: February 26, 2016

Record last verified: 2012-04

Locations

CA (1)