Resistive Exercise for Arthritic Cartilage Health (REACH)

NCT00465660 | Unknown Phase 2

• 1 other identifier: ACTRN012605000116628
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Female subjects over the age of 40 will be recruited and randomised into a progressive resistance training (PRT) or sham-exercise group. The PRT group will train at 80% of their peak strength, using Keiser pneumatic resistance machines, and progress approximately 3% per session. Strength will be re-assessed fortnightly. Exercises will target muscles around the hip and knee. The sham-exercise group will train on the same equipment as the PRT group except hip adduction, but without added resistance or progression. Both groups will train 3 days per week for roughly 45 minutes for 6 months. It is hypothesised that high intensity PRT will decelerate the tibial and femoral cartilage degeneration in the knee affected most by OA. Primary Outcome: Articular cartilage morphology following 6 months high intensity progressive resistance training Secondary Outcomes: Muscle and fat cross-sectional area (CSA) (pre and post) Muscle strength, power, endurance, and contraction velocity (pre, 3 months, \& post) Medications (pre, 3 months, \& post) Body composition (pre, 3 months, \& post) Balance; Physical function (pre, 3 months, \& post) Questionnaires (pre, 3 months, \& post)

• Habitual exercise (PASE) -WOMAC index (pain, stiffness and functional ability)
• Depressive symptoms (Depression Scale) -Quality of life (SF36)
• Confidence performing physical activity (Ewart) -Demographics

Conditions

Osteoarthritis

Keywords

Osteoarthritis; Cartilage; Exercise; Progressive Resistance Training

Outcome Measures

Primary Outcomes (1)

• Articular cartilage morphology following 6 months high intensity progressive resistance training

Secondary Outcomes (12)

• Muscle and fat cross-sectional area (CSA) (pre and post)

• Muscle strength, power, endurance, and contraction velocity (pre, 3 months, & post)

• Medications (pre, 3 months, & post)

• Body composition (pre, 3 months, & post)

• Balance; Physical function (pre, 3 months, & post)

Interventions

Progressive resistance training BEHAVIORAL

Eligibility Criteria

• Age: 40 Years+
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Female
• Aged over 40 years old
• Primary Osteoarthritis in at least one knee using standard criteria of the American College of Rheumatology (ACR) criteria for classification of clinical osteoarthritis
• Ambulatory without human assistance
• Willingness to be randomised to experiential or control group
• Ability to attend scheduled exercise and testing sessions

You may not qualify if:

• Regular exercise of any kind over the past 3 months (\>1dpw).
• Secondary osteoarthritis (traumatic or post-surgical), rheumatic disease, gouty or septic arthritis, Paget's disease, pseudogout, major congenital abnormalities, hemochromatosis, Wilson's disease and other rare forms of arthritis
• Joint injury, injection or surgery within the past 6 months or knee joint replacement
• Contraindications to MRI/Exercise

Sponsors & Collaborators

• University of Sydney: lead

Study Sites (1)

University of Sydney

Sydney, New South Wales, 2140, Australia

Location

MeSH Terms

Conditions

Osteoarthritis; Motor Activity

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Behavior

Study Officials

• Benedicte Vanwanseele, PhD

  University of Sydney

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: SINGLE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: April 24, 2007
• First Posted: April 25, 2007
• Study Start: April 1, 2005
• Study Completion: July 1, 2009
• Last Updated: April 25, 2007

Record last verified: 2006-12

Locations

AU (1)