The Effect of Amputation on Spatial Visual Representation in Peripersonal Space

NCT00458757 | Unknown

• 1 other identifier: 090767-amputy-HMO-CTIL
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

In this study, we wish to find behavioral evidence for the question whether an amputation of the arm can lead to changes in visual perception or motor responses to objects in peripersonal space. We hypothesize that changes in the motor and somatosensory hand-related cortices following amputation might lead to changes in parietal hand-related areas. The consequence of these parietal changes should be reflected behaviorally in reduced perception/attention/responses to hand-related objects in the space ipsilateral to the amputation. We further hypothesize that the use of prosthetics may provide the necessary visual feedback to maintain an intact hand representation and therefore lead to lesser cortical reorganization in both visual and somatosensory cortical areas.

Conditions

Upper Limb Amputees

Keywords

Amputees; Affordance; Peripersonal space; Pseudo neglect; Reaching; Spatial; visual

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

In this experiment we plan to employ a paradigm which is inspired by the affordance effect, originally introduced by Tucker and Elice (1998): we will present subjects with brief images of either manipulable or non manipulable objects in either the left or right visual field. The subjects will be required to determine whether the object contains a metal or not, by moving either their left or their right shoulder. We predict that while the control group of normal subjects would show a congruency effect (that is superior performance (faster and more accurate responses) when the responding shoulder is congruent with the position of the objects, the amputees will show spatial biases towards the non-amputated side. This effect should be more prominent for the manipulable objects.

You may qualify if:

• Upper limb amputee, amputation above wrist.

Sponsors & Collaborators

• Hadassah Medical Organization: lead

Study Sites (1)

Neurobiology Dep., Life Sciences Institute, Hebrew Uni.

Jerusalem, 91904, Israel

Location

Related Publications (2)

• Makin TR, Holmes NP, Zohary E. Is that near my hand? Multisensory representation of peripersonal space in human intraparietal sulcus. J Neurosci. 2007 Jan 24;27(4):731-40. doi: 10.1523/JNEUROSCI.3653-06.2007.

  PMID: 17251412 BACKGROUND

• Tucker M, Ellis R. On the relations between seen objects and components of potential actions. J Exp Psychol Hum Percept Perform. 1998 Jun;24(3):830-46. doi: 10.1037//0096-1523.24.3.830.

  PMID: 9627419 BACKGROUND

MeSH Terms

Conditions

Personal Space

Condition Hierarchy (Ancestors)

Spatial Behavior; Behavior

Study Officials

• Isabella Schuartz, MD

  Rehabilitation Dep. Hadassah Medical Hospital, Mount Scopus, Jerusalem

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Isabella Schuartz, MD

CONTACT

00 972 50 8573783; isabellas@hadassah.org.il

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: April 10, 2007
• First Posted: April 11, 2007
• Study Start: November 1, 2007
• Last Updated: November 30, 2017

Record last verified: 2007-03

Locations

IL (1)