Body Plethysmograph Measurements Before and After Methacholine Challenge in Early Childhood

NCT00458627 | Completed DMC

• 1 other identifier: 2044-CTIL
• Study Type: observational
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

In our previous study of Methacholine Challenge Tests (MCT) in preschool children, we found that wheeze detection was associated with significant reduction in flows and vital capacity values. We hypothesized that this finding is associated with trapped-air rather than the children's loss of cooperation/concentration. Objectives: To test this hypothesis by attempting plethysmography measurements during MCT.

Conditions

Asthma

Keywords

Plethysmograpy; preschool; methacholine challenge; spirometry; asthma

Eligibility Criteria

• Age: 3 Years - 7 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• year-old children who were asthmatic according to GINA guidelines.
• All children previously had recurrent episodes of wheeze, cough and/or shortness of breath with clinical response to bronchodilator.
• Children were included only if they had not received anti-inflammatory medication for at least one week prior to the test or bronchodilators for at least 24 hours prior to the study.
• On the day of testing, children were included if they had normal chest auscultation and FEV1\>75% predicted for healthy preschool children.

You may not qualify if:

• Presence of other chronic respiratory conditions
• Emergency room visit in the past three months
• Respiratory infection in the past month

Sponsors & Collaborators

• Rambam Health Care Campus: lead

Related Publications (4)

• Bentur L, Beck R, Elias N, Barak A, Efrati O, Yahav Y, Vilozni D. Methacholine bronchial provocation measured by spirometry versus wheeze detection in preschool children. BMC Pediatr. 2005 Jun 28;5:19. doi: 10.1186/1471-2431-5-19.

  PMID: 15985169 BACKGROUND

• Vilozni D, Barak A, Efrati O, Augarten A, Springer C, Yahav Y, Bentur L. The role of computer games in measuring spirometry in healthy and "asthmatic" preschool children. Chest. 2005 Sep;128(3):1146-55. doi: 10.1378/chest.128.3.1146.

  PMID: 16162700 BACKGROUND

• Wanger J, Clausen JL, Coates A, Pedersen OF, Brusasco V, Burgos F, Casaburi R, Crapo R, Enright P, van der Grinten CP, Gustafsson P, Hankinson J, Jensen R, Johnson D, Macintyre N, McKay R, Miller MR, Navajas D, Pellegrino R, Viegi G. Standardisation of the measurement of lung volumes. Eur Respir J. 2005 Sep;26(3):511-22. doi: 10.1183/09031936.05.00035005. No abstract available.

  PMID: 16135736 BACKGROUND

• Crapo RO, Casaburi R, Coates AL, Enright PL, Hankinson JL, Irvin CG, MacIntyre NR, McKay RT, Wanger JS, Anderson SD, Cockcroft DW, Fish JE, Sterk PJ. Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. Am J Respir Crit Care Med. 2000 Jan;161(1):309-29. doi: 10.1164/ajrccm.161.1.ats11-99. No abstract available.

  PMID: 10619836 BACKGROUND

MeSH Terms

Conditions

Asthma

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Officials

• Lea Bentur, MD

  Rambam medical Center, Haifa, Israel

  PRINCIPAL INVESTIGATOR

• Daphna Vilozni, PhD

  Rambam Health Care Campus

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: DEFINED POPULATION
• Time Perspective: OTHER
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: April 10, 2007
• First Posted: April 11, 2007
• Study Start: February 1, 2006
• Study Completion: September 1, 2006
• Last Updated: April 11, 2007

Record last verified: 2007-04