NCT00456326

Brief Summary

The purpose of the Heparin Induced Thrombocytopenia Registry is to explore the frequency of heparin-induced thrombocytopenia (HIT) at Brigham and Women's Hospital and to assess its mortality rate. Retrospective 3 years, looking forward prospectively.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
242

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Oct 2005

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2005

Completed
1.5 years until next milestone

First Submitted

Initial submission to the registry

April 2, 2007

Completed
2 days until next milestone

First Posted

Study publicly available on registry

April 4, 2007

Completed
4 months until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2007

Completed
Last Updated

February 18, 2008

Status Verified

February 1, 2008

First QC Date

April 2, 2007

Last Update Submit

February 12, 2008

Conditions

Heparin-Induced Thrombocytopenia

Keywords

HeparinUnfractionated HeparinLow Molecular Weight HeparinAnticoagulationThrombocytopeniaThrombosisVenous ThrombosisPulmonary Embolism

Outcome Measures

Primary Outcomes (3)

  • Incidence of HIT associated with UFH and LMWH

    30 Days

  • Outcomes of patients with HIT

    30 Days

  • Adverse events associated with alternative anticoagulants used to treat HIT

    30 Days

Secondary Outcomes (3)

  • Mortality

    30 Days

  • Hemorrhagic Events

    30 Days

  • Thrombotic Events

    30 Days

Study Arms (1)

HIT Patients

Patients at Brigham and Women's Hospital diagnosed with Heparin Induced Thrombocytopenia.

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients diagnosed with Heparin Induced Thrombocytopenia

All patients hospitalized at BWH who have a PF4-Positive antibody test

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (1)

Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States

Location

Related Publications (1)

  • Baroletti SA, Goldhaber SZ. Heparin-induced thrombocytopenia. Circulation. 2006 Aug 22;114(8):e355-6. doi: 10.1161/CIRCULATIONAHA.106.632653. No abstract available.

    PMID: 16923760BACKGROUND

Related Links

MeSH Terms

Conditions

ThrombocytopeniaThrombosisVenous ThrombosisPulmonary Embolism

Condition Hierarchy (Ancestors)

Blood Platelet DisordersHematologic DiseasesHemic and Lymphatic DiseasesCytopeniaEmbolism and ThrombosisVascular DiseasesCardiovascular DiseasesLung DiseasesRespiratory Tract DiseasesEmbolism

Study Officials

  • Samuel Z. Goldhaber, MD

    Brigham and Women's Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

April 2, 2007

First Posted

April 4, 2007

Study Start

October 1, 2005

Study Completion

August 1, 2007

Last Updated

February 18, 2008

Record last verified: 2008-02

Locations

US(1)