NCT00454311|Completed
The Impact of the Biopsy of 1-2 Cells in a PGD Program for Anueploidy Screening
Prospective and Randomized Study of the Impact of the Biopsy of 1-2 Cells in a PGD Program for Aneuploidy Screening
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Prospective and Randomized Study of the Impact of the Biopsy of 1-2 Cells in a PGD Program for Aneuploidy Screening
Sponsor study identifier
interventional
N/A
1 country
1
Study Start
November 2007
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
December 2008
Actual (reported)Study Completion
December 2008
Actual (reported)The aim of this study is to evaluate the impact of the biopsy of one or two cells in a preimplantatation genetic diagnosis program (PGD) for the screening of aneuploidies. This prospective and randomized study will be performed at the Instituto Valenciano de Infertilidad in Valencia (Spain) in those patientes included in our clinical program. Our purpose is to optimize the methodology employed in our laboratory in order to guarantee optimal implantation and pregnancy rates without a detrimental effect on the accuracy and efficiency of the cytogenetic analysis. Patients will undergo and IVF cycle, embryo biopsy will be performed on day 3 embryos in two fashions: in some patients only one cell per embryo will be retrieved whereas in others, 2 cells will be retrieved in good morphology embryos and only 1 in the slowl ones. In all cases aneuploidy screening will be performed by FISH for chromosomes 13, 16, 18, 21, 22, X and Y. Embryo developmente will be checked every 24 hours and chormosomally normal embryos will be replaced into the uterus on day 5 of development.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2008
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 29, 2007
Actual (reported)March 30, 2007
Actual (reported)November 2007
Date type not reportedThis date has not been verified as actual or estimated.
December 2008
Actual (reported)December 2008
Actual (reported)impact of biopsy
8 days
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Instituto Valenciano de la Infertilidad
Valencia, 46015, Spain
Carmen Rubio, PhD
Instituto Valenciano de Infertilidad
First Submitted
March 29, 2007
First Posted
March 30, 2007
Study Start
November 2007
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
December 2008
Actual (reported)An Interaction Study to Assess Drug Levels in Healthy Adult Subjects
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Study Completion
December 2008
Actual (reported)Last Updated
March 4, 2011
Record last verified: 2011-03
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Source: ClinicalTrials.gov.
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