NCT00452998

Brief Summary

Sequential Laser Iridotomy uses argon and Nd:yag laser in the first and second steps, respectively. Using q-switched 532 nm laser in the second step is hypothesized to be as good and effective as the conventional Nd:yag laser, because it selectively targets pigmented cells and delivers a short pulse duration of 3 nanoseconds, causing less thermal and collateral damage.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
10

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Nov 2006

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2006

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

March 27, 2007

Completed
1 day until next milestone

First Posted

Study publicly available on registry

March 28, 2007

Completed
8 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2007

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2007

Completed
Last Updated

May 14, 2008

Status Verified

May 1, 2008

Enrollment Period

1.1 years

First QC Date

March 27, 2007

Last Update Submit

May 12, 2008

Conditions

Chronic Angle Closure GlaucomaPrimary Angle ClosurePrimary Angle Closure SuspectFellow Eyes of Acute Angle Closure Glaucoma

Keywords

Sequential Laser IridotomyQ-Switched 532 nm LaserFrequency Doubled Neodymium Yag Laser

Outcome Measures

Primary Outcomes (9)

  • Visual Acuity

  • Intraocular pressure

  • Total power delivered by each laser modality

  • Iridotomy patency and size

  • Pain rating during the procedure

  • Anterior segment inflammation

  • Endothelial cell count

  • Cataract progression

  • Rate of complications

Interventions

Q-switched fd Nd:yag in Laser IridotomyPROCEDURE

Eligibility Criteria

Age22 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • More than 21 years old
  • Able to give informed consent
  • Diagnosis of either: chronic angle closure glaucoma (CACG), primary angle closure (PAC), primary angle closure suspect (PACS) or fellow eyes of acute angle closure glaucoma (AACG), and in need of a laser iridotomy

You may not qualify if:

  • History of any prior laser treatment or intraocular surgery to the eye
  • History of any corneal disease
  • Any ocular infection/ inflammation within the last two months
  • Inability to give informed consent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

National University Hospital

Singapore, 119074, Singapore

Location

Related Publications (1)

  • Latina MA, Park C. Selective targeting of trabecular meshwork cells: in vitro studies of pulsed and CW laser interactions. Exp Eye Res. 1995 Apr;60(4):359-71. doi: 10.1016/s0014-4835(05)80093-4.

    PMID: 7789416BACKGROUND

Study Officials

  • Paul Chew, FRCSEd,MMed

    National University Hospital, Singapore

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER

Study Record Dates

First Submitted

March 27, 2007

First Posted

March 28, 2007

Study Start

November 1, 2006

Primary Completion

December 1, 2007

Study Completion

December 1, 2007

Last Updated

May 14, 2008

Record last verified: 2008-05

Locations

SG(1)