The Effect of Parathyroidectomy on Renal Function, Endothelial Function, and Blood Pressure

NCT00452049 | Unknown

• 1 other identifier: ML3052
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Secondary hyperparathyroidism (HPT) is a known complication of chronic renal failure. Elevated concentrations of parathyroid hormone (PTH) play a role not only in the pathogenesis of renal bone disease, but also in the development of cardiovascular risk factors such as disturbed lipid metabolism, glucose intolerance, and hypertension. HPT is also known to play an important role in the development of structural abnormalities of both large arteries and the heart (left ventricular hypertrophy, interstitial fibrosis). In the last couple of years there has been increasing evidence from animal studies that the endothelium is a target organ of PTH. Hypothesis: PTH has clinically relevant effects on renal hemodynamics, renal function and endothelial function. Aims:

1. 1.To evaluate the effect of parathyroidectomy (PTX) on renal hemodynamics in stable renal transplant recipients
2. 2.To evaluate the effect of PTX on endothelial function in stable renal transplant recipients/chronic kidney disease (CKD) stage 5 patients
3. 3.To evaluate the effect of PTX on blood pressure in stable renal transplant recipients/CKD stage 5 patients

Conditions

Hyperparathyroidism; Hypertension

Keywords

parathyroidectomy; arterial stiffness; renal function

Interventions

parathyroidectomy PROCEDURE

parathyroidectomy

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Renal transplant recipients

You may qualify if:

• Stable renal transplant recipients/CKD stage 5D patients.
• Age between 18 years and 85 years.
• Signed informed consent.
• PTX scheduled because of severe hyperparathyroidism (day 0)

Sponsors & Collaborators

• Universitaire Ziekenhuizen KU Leuven: lead

Study Sites (1)

University Hopsital Leuven

Leuven, 3000, Belgium

RECRUITING

Related Publications (1)

• Evenepoel P, Claes K, Viaene L, Bammens B, Meijers B, Naesens M, Sprangers B, Kuypers D. Decreased Circulating Sclerostin Levels in Renal Transplant Recipients With Persistent Hyperparathyroidism. Transplantation. 2016 Oct;100(10):2188-93. doi: 10.1097/TP.0000000000001311.

  PMID: 27379556 DERIVED

MeSH Terms

Conditions

Hyperparathyroidism; Hypertension

Interventions

Parathyroidectomy

Condition Hierarchy (Ancestors)

Parathyroid Diseases; Endocrine System Diseases; Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Endocrine Surgical Procedures; Surgical Procedures, Operative

Study Officials

• Pieter Evenepoel, MD, PhD

  Universitaire Ziekenhuizen KU Leuven

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Pieter Evenepoel, MD, PhD

CONTACT

003216344580; pieter.evenepoel@uz.kuleuven.ac.be

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, PhD

Study Record Dates

• First Submitted: March 23, 2007
• First Posted: March 26, 2007
• Study Start: April 1, 2005
• Last Updated: May 30, 2012

Record last verified: 2012-05

Locations

BE (1)