NCT00449631

Brief Summary

We investigate whether mitomycin C treatment during previous filtration surgery induces P-glycoprotein expression.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 19, 2007

Completed
1 day until next milestone

First Posted

Study publicly available on registry

March 20, 2007

Completed
Last Updated

March 26, 2007

Status Verified

March 1, 2007

First QC Date

March 19, 2007

Last Update Submit

March 23, 2007

Conditions

GlaucomaTrabeculectomy

Keywords

GlaucomaDrug Resistance, MultipleTrabeculectomy

Eligibility Criteria

Age8 Years - 85 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • patients with planned trabeculectomy for elevated eye pressure
  • one third of patients without previous trabeculectomy
  • two thirds of patients with previous trabeculectomy (one third with and one third without the use of mitomycin C)

You may not qualify if:

  • patients not requiring surgery
  • patients with planned surgery for elevated eye pressure other than trabeculectomy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

The University Hospital of Cologne

Cologne, 50924, Germany

Location

Related Publications (1)

  • Hueber A, Esser JM, Kociok N, Welsandt G, Luke C, Roters S, Esser PJ. Mitomycin C induces multidrug resistance in glaucoma surgery. Graefes Arch Clin Exp Ophthalmol. 2008 Feb;246(2):297-304. doi: 10.1007/s00417-007-0695-1. Epub 2007 Oct 13.

    PMID: 17934748DERIVED

MeSH Terms

Conditions

Glaucoma

Condition Hierarchy (Ancestors)

Ocular HypertensionEye Diseases

Study Officials

  • Arno Hueber, MD

    University of Cologne

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Time Perspective
OTHER
Sponsor Type
OTHER

Study Record Dates

First Submitted

March 19, 2007

First Posted

March 20, 2007

Last Updated

March 26, 2007

Record last verified: 2007-03

Locations

DE(1)