NCT00443833

Brief Summary

Thyrotoxic periodic paralysis (TPP) is characterized by episodes of reversible hypokalemia and weakness in thyrotoxic patients. It is commonly found in males of Asian descent and is also seen in individuals having Native American or Hispanic ancestry. Therefore genetic etiology has been hypothesized. This study, we aim to find the susceptibility genes that associate with TPP. Both candidate genes approach and genome wide association study have been conducted.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
80

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Jan 2004

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2004

Completed
1.9 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2005

Completed
1.3 years until next milestone

First Submitted

Initial submission to the registry

March 5, 2007

Completed
1 day until next milestone

First Posted

Study publicly available on registry

March 6, 2007

Completed
Last Updated

March 6, 2007

Status Verified

March 1, 2007

First QC Date

March 5, 2007

Last Update Submit

March 5, 2007

Conditions

Thyrotoxic Periodic Paralysis

Keywords

Thyrotoxicosisgenetic association studyperiodic paralysiswhole genome scan

Eligibility Criteria

Age15 Years+
Sexmale
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • TPP
  • Hyperthyroid patients from any causes
  • Evidence of hypokalemia (k\<3.5 mg/dl)from intracellular shift (Urine K\<15 mg/dl, TTKG\<2)
  • Episodic paralysis

You may not qualify if:

  • Hypokalemia from GI or renal loss

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Thyrotoxicosis

Condition Hierarchy (Ancestors)

HyperthyroidismThyroid DiseasesEndocrine System Diseases

Study Officials

  • Wallaya Jongjaroenprasert, MD

    Endocrinology Unit, Ramathibodi Hospital, Mahidol University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
OTHER
Sponsor Type
OTHER

Study Record Dates

First Submitted

March 5, 2007

First Posted

March 6, 2007

Study Start

January 1, 2004

Study Completion

December 1, 2005

Last Updated

March 6, 2007

Record last verified: 2007-03