Response of Older Adults to Influenza Vaccination With Regard to Cytomegalovirus (CMV) Status
CMVflu
A Phase IV, Single Group Study to Evaluate the Immune Response to Licensed Seasonal Influenza Vaccine and Relationship of This to Cytomegalovirus-associated Immunosenescence in UK Older Adults Aged 50-80 Years
2 other identifiers
interventional
100
1 country
1
Brief Summary
The study is being undertaken to evaluate responses to seasonal influenza vaccine in older adults with respect to their CMV status. CMV is cytomegalovirus and is an organism that infects many people, but does not usually cause disease in the individual unless they are immunocompromised i.e. their immune system is not working well such as in the case of HIV infection. CMV is believed to have infected up to 80% of individuals in the age group we will be looking at in our study and we are interested in whether this infection affects their responses to vaccination.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_4
Started Mar 2007
Shorter than P25 for phase_4
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2007
CompletedFirst Submitted
Initial submission to the registry
March 2, 2007
CompletedFirst Posted
Study publicly available on registry
March 5, 2007
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2007
CompletedAugust 29, 2018
February 1, 2008
March 2, 2007
August 28, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Response to influenza vaccination (HI)
Interventions
Eligibility Criteria
You may qualify if:
- No contraindications to vaccination as specified in the "Green Book" - Immunisation Against Infectious Disease, HMSO.
- Written informed consent obtained
- Subject aged no less than 50 years 0 days and no older than 79 years and 364 days at enrollment.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Hertfordshire Primary Care Trust
Stevenage, United Kingdom
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Elizabeth Miller, MBBS FRCPath
Public Health England
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- PREVENTION
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER GOV
Study Record Dates
First Submitted
March 2, 2007
First Posted
March 5, 2007
Study Start
March 1, 2007
Study Completion
September 1, 2007
Last Updated
August 29, 2018
Record last verified: 2008-02