The Revolutions of Helicobacter Pylori Infection, Bacterial Density, and Histological Features After Antrectomy

NCT00441831 | Unknown DMC

• 1 other identifier: MMH-I-S-261
• Study Type: observational
• Target: 65
• Locations: 1 country
• Sites: 1

Brief Summary

Helicobacter pylori (HP) is a gram-negative bacillus responsible for one of the most common infections found in humans worldwide. By the early-to-mid 1990s, further evidence emerged supporting the link between the chronic gastritis of HP infection and malignancy in adults, specifically gastric lymphoma and adenocarcinoma. The potential of HP eradication for the prevention of gastric cancer was underlined. At the national consensus meeting held in Brussels in 1998, HP eradication was strongly recommended in past or current peptic ulcer diseases, regardless of activity, complication and post endoscopic resection of early cancer. Some patients received gastric surgery due to the complications of peptic ulcer such as bleeding or perforation in the pre-HP eradication era. Their HP infection status was not surveyed and unknown at the time. Afterward, some of them were not suggested to receive an eradication therapy and recovered from the operative procedure. According to the consensus to treat HP for a purpose to reduce the risk of gastric cancer, these patients were still under risk. There have been only a few surveys on the prevalence of persistent HP infection in patients who have undergone surgery. The aim of the study was to evaluate the prevalence and histological features of HP infection after a time course of partial distal gastric surgery.

Conditions

Helicobacter Pylori Infection; Peptic Ulcer; Bile Reflux; Gastritis

Keywords

Helicobacter pylori infection; peptic ulcer disease; distal partial gastrectomy; bile reflux; gastritis; gastrectomy

Eligibility Criteria

• Age: 15 Years - 95 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients with previous distal gastrectomy

You may qualify if:

• Previous distal gastrectomy

You may not qualify if:

• Post HP eradication therapy

Sponsors & Collaborators

• Mackay Memorial Hospital: lead

Study Sites (1)

Division of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital

Taipei, Taiwan

RECRUITING

Related Publications (4)

• Fukuhara K, Osugi H, Takada N, Takemura M, Lee S, Taguchi S, Kaneko M, Tanaka Y, Fujiwara Y, Nishizawa S, Kinoshita H. Duodenogastric reflux eradicates Helicobacter pylori after distal gastrectomy. Hepatogastroenterology. 2004 Sep-Oct;51(59):1548-50.

  PMID: 15362798 BACKGROUND

• Huang WH, Wang HH, Wu WW, Lai HC, Hsu CH, Cheng KS. Helicobacter pylori infection in patients with ulcer recurrence after partial gastrectomy. Hepatogastroenterology. 2004 Sep-Oct;51(59):1551-3.

  PMID: 15362799 BACKGROUND

• Malfertheiner P, Megraud F, O'Morain C, Bazzoli F, El-Omar E, Graham D, Hunt R, Rokkas T, Vakil N, Kuipers EJ. Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report. Gut. 2007 Jun;56(6):772-81. doi: 10.1136/gut.2006.101634. Epub 2006 Dec 14.

  PMID: 17170018 BACKGROUND

• Johannesson KA, Hammar E, Stael von Holstein C. Mucosal changes in the gastric remnant: long-term effects of bile reflux diversion and Helicobacter pylori infection. Eur J Gastroenterol Hepatol. 2003 Jan;15(1):35-40. doi: 10.1097/00042737-200301000-00007.

  PMID: 12544692 BACKGROUND

MeSH Terms

Conditions

Peptic Ulcer; Bile Reflux; Gastritis

Condition Hierarchy (Ancestors)

Duodenal Diseases; Intestinal Diseases; Gastrointestinal Diseases; Digestive System Diseases; Stomach Diseases; Biliary Tract Diseases; Duodenogastric Reflux; Gastroenteritis

Study Officials

• Ming-Jen Chen, M.D.,M.S.

  Mackay Memorial Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Wan-Ting Chen

CONTACT

886-2-25433535; wanting.b352@ms1.mmh.org.tw

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: February 27, 2007
• First Posted: March 1, 2007
• Study Start: February 1, 2007
• Study Completion: February 1, 2008
• Last Updated: February 5, 2009

Record last verified: 2009-02

Locations

TW (1)