Anesthesia in Flexible Bronchoscopy for Lung Cancer Diagnostic

NCT00440960 | Completed Phase 4

• 1 other identifier: 0002.0.297.000-06
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 3

Brief Summary

The objective of the study was to establish which anesthetic procedure used during flexible bronchoscopy has the lowest index of complications.

Conditions

Lung Cancer

Keywords

alfentanil; anesthesia; bronchoscopy; lidocaine; midazolam; propofol.

Interventions

propofol DRUG

midazolam DRUG

alfentanil DRUG

lidocaine DRUG

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• The patients included in this study were referred to FBC for the investigation of bronchial carcinoma (diagnostic procedure).
• Patients included in the study were classified as ASA I, II and II according to the anesthetic risk classification of the American Society of Anesthesiologists (ASA).

You may not qualify if:

• ASA IV classification of anesthesiology risk
• procedure that lasted longer than 15 minutes
• indication of therapeutic bronchoscopy
• cardiac arrhythmia and / or hypoxemia detected at admission.

Sponsors & Collaborators

• Hospital Pompeia: lead

Study Sites (3)

Hospital Pompeia

Caxias do Sul, Rio Grande do Sul, 95010-005, Brazil

Location

Hospital Medianeira

Caxias do Sul, Rio Grande do Sul, 95040-000, Brazil

Location

General Hospital of Universidade de Caxias do Sul

Caxias do Sul, Rio Grande do Sul, 95070-560, Brazil

Location

Related Publications (9)

• Pue CA, Pacht ER. Complications of fiberoptic bronchoscopy at a university hospital. Chest. 1995 Feb;107(2):430-2. doi: 10.1378/chest.107.2.430.

  PMID: 7842773 BACKGROUND

• Barr J, Egan TD, Sandoval NF, Zomorodi K, Cohane C, Gambus PL, Shafer SL. Propofol dosing regimens for ICU sedation based upon an integrated pharmacokinetic-pharmacodynamic model. Anesthesiology. 2001 Aug;95(2):324-33. doi: 10.1097/00000542-200108000-00011.

  PMID: 11506101 RESULT

• Schaeuble J, Heidegger T, Gerig HJ, Ulrich B, Schnider TW. Comparision of etomidate and propofol for fibreoptic intubation as part of an airway management algorithm:a prospective, randomizes, double-blind study. Eur J Anaesthesiol. 2005 Oct;22(10):762-7. doi: 10.1017/s0265021505001262.

  PMID: 16211735 RESULT

• Amitai Y, Zylber-Katz E, Avital A, Zangen D, Noviski N. Serum lidocaine concentrations in children during bronchoscopy with topical anesthesia. Chest. 1990 Dec;98(6):1370-3. doi: 10.1378/chest.98.6.1370.

  PMID: 2245677 RESULT

• Koyama S, Koh H, Noda K, Tagami N, Asada A. [A comparison of the incidence of postoperative nausea and vomiting after propofol-fentanyl anesthesia and that after nitrous oxide-isoflurane anesthesia]. Masui. 1998 Mar;47(3):286-9. Japanese.

  PMID: 9560538 RESULT

• Hautmann H, Bauer M, Pfeifer KJ, Huber RM. Flexible bronchoscopy: a safe method for metal stent implantation in bronchial disease. Ann Thorac Surg. 2000 Feb;69(2):398-401. doi: 10.1016/s0003-4975(99)01398-3.

  PMID: 10735670 RESULT

• Cartwright CR, Henson LC, Ward DS. Effects of alfentanil on the ventilatory response to sustained hypoxia. Anesthesiology. 1998 Sep;89(3):612-9. doi: 10.1097/00000542-199809000-00009.

  PMID: 9743396 RESULT

• Pereira W Jr, Kovnat DM, Snider GL. A prospective cooperative study of complications following flexible fiberoptic bronchoscopy. Chest. 1978 Jun;73(6):813-6. doi: 10.1378/chest.73.6.813.

  PMID: 657853 RESULT

• Clarkson K, Power CK, O'Connell F, Pathmakanthan S, Burke CM. A comparative evaluation of propofol and midazolam as sedative agents in fiberoptic bronchoscopy. Chest. 1993 Oct;104(4):1029-31. doi: 10.1378/chest.104.4.1029.

  PMID: 8404160 RESULT

MeSH Terms

Conditions

Lung Neoplasms

Interventions

Propofol; Midazolam; Alfentanil; Lidocaine

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Phenols; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons; Organic Chemicals; Benzodiazepines; Benzazepines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Heterocyclic Compounds; Fentanyl; Piperidines; Heterocyclic Compounds, 1-Ring; Acetanilides; Anilides; Amides; Aniline Compounds; Amines

Study Officials

• Andre GS Leite, PhD

  Brazilian Society of Thoracic Surgery

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: RANDOMIZED
• Masking: SINGLE
• Purpose: TREATMENT
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: February 26, 2007
• First Posted: February 27, 2007
• Last Updated: February 27, 2007

Record last verified: 2007-02

Locations

BR (3)