Oral Bacteria and Allergic Disease in Children

NCT00438646 | Completed

• 2 other identifiers: 99990710907-E-N109
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This study will see if bacteria differ between children who have allergies or asthma and children who do not have allergies or asthma. Previous research suggests that some bacteria may protect against allergies and asthma. This study may provide more information on why some children develop allergies and asthma. Patients at the University of North Carolina-Chapel Hill School of Dentistry who are between 6 and 11 years of age may be eligible for this study. Parents of participating children complete a questionnaire about the child and the child's health. The child provides a saliva sample by chewing a small piece of wax and spitting in a cup. The saliva sample is analyzed in the laboratory for bacteria, yeast and antibodies (substances the body produces to fight germs). ...

Conditions

Asthma; Rhinitis; Eczema; Respiratory Sounds; Hypersensitivity

Keywords

Allergy; Asthma; Eczema; Hay Fever; Epidemiology

Eligibility Criteria

• Age: 6 Years - 11 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• Aged 6-11 years.
• Child is presenting to the UNC-CH School of Dentistry for a scheduled appointment.
• Sibling has not been enrolled.
• Parent consents to child's participation.
• Parent is willing to provide answers to a questionnaire.
• Child assents to the study.
• Child is willing and able to provide a usable saliva sample.

You may not qualify if:

• Child is unwilling or unable to provide a usable saliva sample.
• Parent or child is non-English speaking.

Sponsors & Collaborators

• National Institute of Environmental Health Sciences (NIEHS): lead

Study Sites (1)

University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, United States

Location

Related Publications (3)

• Mannino DM, Homa DM, Akinbami LJ, Moorman JE, Gwynn C, Redd SC. Surveillance for asthma--United States, 1980-1999. MMWR Surveill Summ. 2002 Mar 29;51(1):1-13.

  PMID: 12420904 BACKGROUND

• Arbes SJ Jr, Gergen PJ, Elliott L, Zeldin DC. Prevalences of positive skin test responses to 10 common allergens in the US population: results from the third National Health and Nutrition Examination Survey. J Allergy Clin Immunol. 2005 Aug;116(2):377-83. doi: 10.1016/j.jaci.2005.05.017.

  PMID: 16083793 BACKGROUND

• Liu AH, Murphy JR. Hygiene hypothesis: fact or fiction? J Allergy Clin Immunol. 2003 Mar;111(3):471-8. doi: 10.1067/mai.2003.172.

  PMID: 12642824 BACKGROUND

MeSH Terms

Conditions

Asthma; Rhinitis; Eczema; Respiratory Sounds; Hypersensitivity; Rhinitis, Allergic, Seasonal

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Immune System Diseases; Respiratory Tract Infections; Infections; Nose Diseases; Otorhinolaryngologic Diseases; Dermatitis; Skin Diseases; Skin and Connective Tissue Diseases; Skin Diseases, Eczematous; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Rhinitis, Allergic

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH

Study Record Dates

• First Submitted: February 21, 2007
• First Posted: February 22, 2007
• Study Start: February 1, 2007
• Primary Completion: December 1, 2008
• Last Updated: August 25, 2009

Record last verified: 2008-11

Locations

US (1)