NCT00427024

Brief Summary

Previous studies in animals revealed, that the activity of certain transporters along the nephron is changed with acute rejection after renal transplantation. We intend to investigate underlying mechanisms occurring in man in renal biopsy specimens obtained from patients because of acute rejection of the transplant or chronic transplant nephropathy.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
200

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Feb 2007

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 25, 2007

Completed
1 day until next milestone

First Posted

Study publicly available on registry

January 26, 2007

Completed
6 days until next milestone

Study Start

First participant enrolled

February 1, 2007

Completed
2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2009

Completed
Last Updated

February 6, 2007

Status Verified

February 1, 2007

First QC Date

January 25, 2007

Last Update Submit

February 5, 2007

Conditions

Kidney TransplantationHost vs Graft Reaction

Keywords

renal transplantationacute rejectiontransporttransporteracute rejection after renal transplantation

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • individuals transplanted with a donor kidney
  • individuals with acute transplant rejection

You may not qualify if:

  • pregnancy
  • malignant disease
  • HIV infection

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Hospital Münster

Münster, 48149, Germany

Location

Related Publications (2)

  • Velic A, Gabriels G, Hirsch JR, Schroter R, Edemir B, Paasche S, Schlatter E. Acute rejection after rat renal transplantation leads to downregulation of NA+ and water channels in the collecting duct. Am J Transplant. 2005 Jun;5(6):1276-85. doi: 10.1111/j.1600-6143.2005.00890.x.

    PMID: 15888031BACKGROUND

  • Velic A, Hirsch JR, Bartel J, Thomas R, Schroter R, Stegemann H, Edemir B, August C, Schlatter E, Gabriels G. Renal transplantation modulates expression and function of receptors and transporters of rat proximal tubules. J Am Soc Nephrol. 2004 Apr;15(4):967-77. doi: 10.1097/01.asn.0000117287.74203.89.

    PMID: 15034099BACKGROUND

Study Officials

  • Gert Gabriëls, PD Dr. med.

    University Hospital Münster

    STUDY CHAIR

Central Study Contacts

Gert Gabriëls, PD Dr. med.

CONTACT

0049-251-83-47676gabrie@uni-muenster.de

Hermann Pavenstädt, Prof. Dr. med.

CONTACT

0049-251-83-47516Hermann.Pavenstaedt@ukmuenster.de

Study Design

Study Type
observational
Observational Model
DEFINED POPULATION
Time Perspective
OTHER
Sponsor Type
OTHER

Study Record Dates

First Submitted

January 25, 2007

First Posted

January 26, 2007

Study Start

February 1, 2007

Study Completion

February 1, 2009

Last Updated

February 6, 2007

Record last verified: 2007-02

Locations

DE(1)