Characteristics of Blood- Brain Barrier Permeability in Neurological Patients

NCT00419874 | Unknown

• 1 other identifier: SOR444206CTIL
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The main goal of the present study is to challenge the hypothesis that blood- brain barrier disruption following brain injury increases the risk for long-term disability, development of brain dysfunction, epileptic seizures and neuroanatomical alterations.

Conditions

Traumatic Brain Injury; Cerebral Infarction; Cerebral Hemorrhage

Keywords

Blood-brain barrier; Post traumatic epilepsy; Seizures

Eligibility Criteria

• Age: 16 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• One week following:
• Traumatic Brain Injury
• Cerebro- Vascular Accident
• Subsequent brain CT showed cerebral cortex injury.

You may not qualify if:

• A known ailment of the central nervous system.
• Use of medications or illicit drugs that significantly affect the central nervous system.
• tourist or temporary residents not available for follow-up.
• For MRI examinations: heart pacemaker, metal implants, or metal shrapnel.

Sponsors & Collaborators

• Soroka University Medical Center: lead

Study Sites (1)

Soroka University Medical Center

Beersheba, Israel

RECRUITING

Related Publications (4)

• Tomkins O, Friedman O, Ivens S, Reiffurth C, Major S, Dreier JP, Heinemann U, Friedman A. Blood-brain barrier disruption results in delayed functional and structural alterations in the rat neocortex. Neurobiol Dis. 2007 Feb;25(2):367-77. doi: 10.1016/j.nbd.2006.10.006. Epub 2006 Dec 22.

  PMID: 17188501 BACKGROUND

• Ivens S, Kaufer D, Flores LP, Bechmann I, Zumsteg D, Tomkins O, Seiffert E, Heinemann U, Friedman A. TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis. Brain. 2007 Feb;130(Pt 2):535-47. doi: 10.1093/brain/awl317. Epub 2006 Nov 21.

  PMID: 17121744 BACKGROUND

• Dreier JP, Jurkat-Rott K, Petzold GC, Tomkins O, Klingebiel R, Kopp UA, Lehmann-Horn F, Friedman A, Dichgans M. Opening of the blood-brain barrier preceding cortical edema in a severe attack of FHM type II. Neurology. 2005 Jun 28;64(12):2145-7. doi: 10.1212/01.WNL.0000176298.63840.99.

  PMID: 15985592 BACKGROUND

• Seiffert E, Dreier JP, Ivens S, Bechmann I, Tomkins O, Heinemann U, Friedman A. Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex. J Neurosci. 2004 Sep 8;24(36):7829-36. doi: 10.1523/JNEUROSCI.1751-04.2004.

  PMID: 15356194 BACKGROUND

MeSH Terms

Conditions

Brain Injuries, Traumatic; Cerebral Infarction; Cerebral Hemorrhage; Epilepsy, Post-Traumatic; Seizures

Condition Hierarchy (Ancestors)

Brain Injuries; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries; Brain Infarction; Brain Ischemia; Cerebrovascular Disorders; Stroke; Vascular Diseases; Cardiovascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis; Intracranial Hemorrhages; Hemorrhage; Epilepsy; Neurologic Manifestations; Signs and Symptoms

Study Officials

• Alon Friedman, MD/PhD

  Soroka University Medical Center

  PRINCIPAL INVESTIGATOR

• Ilan Shelef, MD

  Soroka University Medical Center

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Alon Friedman, MD/PhD

CONTACT

alonf@bgu.ac.il

Study Design

• Study Type: observational
• Observational Model: DEFINED POPULATION
• Time Perspective: OTHER
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: January 7, 2007
• First Posted: January 9, 2007
• Last Updated: January 9, 2007

Record last verified: 2006-11

Locations

IL (1)