NCT00419393

Brief Summary

To provide continued treatment of Keppra XR (Levetiracetam XR) and to assess the long term safety of Keppra XR in subjects with partial onset seizures.

Trial Health

90
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
190

participants targeted

Target at P25-P50 for phase_3

Timeline
Completed

Started Dec 2007

Geographic Reach
4 countries

35 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 4, 2007

Completed
4 days until next milestone

First Posted

Study publicly available on registry

January 8, 2007

Completed
11 months until next milestone

Study Start

First participant enrolled

December 1, 2007

Completed
2.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2010

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2010

Completed
1.4 years until next milestone

Results Posted

Study results publicly available

July 13, 2011

Completed
Last Updated

September 5, 2014

Status Verified

June 1, 2011

Enrollment Period

2.2 years

First QC Date

January 4, 2007

Results QC Date

March 25, 2011

Last Update Submit

August 26, 2014

Conditions

Keywords

Keppra XRLevetiracetam XRlong termpartial seizures

Outcome Measures

Primary Outcomes (3)

  • Number of Subjects Who Experienced at Least 1 Treatment Emergent Adverse Event During the Actual Treatment Period (6 Months-2 Years)

    An adverse event is any untoward medical occurrence in a patient or clinical investigation subject administered a pharmaceutical product which does not necessarily have a causal relationship with this treatment.

    Duration of the Treatment Period (6 months-2 years)

  • Number of Subjects Who Experienced at Least 1 Serious Treatment Emergent Adverse Event During the Actual Treatment Period (6 Months-2 Years)

    A serious adverse event is any untoward medical occurrences in a subject administered study treatment, whether or not the event is related to treatment, with at least one of the follow outcomes: death, life-threatening, initial inpatient hospitalization or prolongation of hospitalization, significant or persistent disability/incapacity, congenital anomaly/birth defect, or an important medical event that may jeopardize the subject and require a medical/surgical intervention.

    Duration of the Treatment Period (6 months-2 years)

  • Number of Subjects Prematurely Discontinuing Due to a Treatment-emergent Adverse Event During the Actual Treatment Period

    An adverse event is any untoward medical occurrence in a patient or clinical investigation subject administered a pharmaceutical product which does not necessarily have a causal relationship with this treatment.

    Duration of the Treatment Period (6 months-2 years)

Secondary Outcomes (2)

  • Percentage of Subjects Remaining on Keppra XR Monotherapy From Study Entry Through 6 Months

    Study entry through 6 months

  • Percentage of Subjects Remaining on Keppra XR Monotherapy From Study Entry Through 12 Months

    Study entry through 12 months

Study Arms (1)

Keppra XR (Levetiracetam XR)

EXPERIMENTAL

1000 - 3000 mg/day Keppra XR (Levetiracetam XR), flexible dosing, throughout the duration of the study (planned: approximately 6 months-3 years)

Drug: Keppra XR (Levetiracetam XR)

Interventions

500 mg tablets, 1000 - 3000 mg/day, flexible dosing for duration of the study (planned: approximately 6 months-3 years).

Also known as: Keppra XR
Keppra XR (Levetiracetam XR)

Eligibility Criteria

Age12 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Subjects who were randomized into study N01280 \[NCT00419094\], and completed the 2 week up titration period

You may not qualify if:

  • Subjects who were discontinued prior to the end of titration period

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (35)

Unknown Facility

Dothan, Alabama, United States

Location

Unknown Facility

Northport, Alabama, United States

Location

Unknown Facility

Phoenix, Arizona, United States

Location

Unknown Facility

Little Rock, Arkansas, United States

Location

Unknown Facility

Bakersfield, California, United States

Location

Unknown Facility

Loxahatchee Groves, Florida, United States

Location

Unknown Facility

Atlanta, Georgia, United States

Location

Unknown Facility

Suwanee, Georgia, United States

Location

Unknown Facility

Witchita, Kansas, United States

Location

Unknown Facility

Detroit, Michigan, United States

Location

Unknown Facility

Camden, New Jersey, United States

Location

Unknown Facility

Buffalo, New York, United States

Location

Unknown Facility

Cedarhurst, New York, United States

Location

Unknown Facility

Toledo, Ohio, United States

Location

Unknown Facility

Tulsa, Oklahoma, United States

Location

Unknown Facility

San Antonio, Texas, United States

Location

Unknown Facility

Aguascalientes, Mexico

Location

Unknown Facility

Guadalajara, Mexico

Location

Unknown Facility

Guadalajara Jalisco, Mexico

Location

Unknown Facility

Mexico City, Mexico

Location

Unknown Facility

Monterrey, Mexico

Location

Unknown Facility

Bialystok, Poland

Location

Unknown Facility

Gdansk, Poland

Location

Unknown Facility

Katowice, Poland

Location

Unknown Facility

Lodz, Poland

Location

Unknown Facility

Lublin, Poland

Location

Unknown Facility

Poznan, Poland

Location

Unknown Facility

Szczecin, Poland

Location

Unknown Facility

Warsaw, Poland

Location

Unknown Facility

Kalingrad, Russia

Location

Unknown Facility

Kazan', Russia

Location

Unknown Facility

Moscow, Russia

Location

Unknown Facility

Saint Petersburg, Russia

Location

Unknown Facility

Samara, Russia

Location

Unknown Facility

Yaroslavl, Russia

Location

Related Links

MeSH Terms

Conditions

EpilepsySeizures

Interventions

Levetiracetam

Condition Hierarchy (Ancestors)

Brain DiseasesCentral Nervous System DiseasesNervous System DiseasesNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

AcetamidesAmidesOrganic ChemicalsAcetatesAcids, AcyclicCarboxylic AcidsPyrrolidinonesPyrrolidinesHeterocyclic Compounds, 1-RingHeterocyclic Compounds

Results Point of Contact

Title
UCB (Study Director)
Organization
UCB Clinical Trial Call Center

Study Officials

  • UCB Clinical Trial Call Center, MD

    +1 877 822 9493 (UCB)

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
OTHER
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
phase 3
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 4, 2007

First Posted

January 8, 2007

Study Start

December 1, 2007

Primary Completion

March 1, 2010

Study Completion

March 1, 2010

Last Updated

September 5, 2014

Results First Posted

July 13, 2011

Record last verified: 2011-06

Locations