NCT00417950

Brief Summary

To understand if acarbose, an alpha-glucosidase inhibitor usually for treating diabetes, will further lower post meal glucose and inflammatory state when taking together with moderate amount of alcohol during meal tolerance test in subjects with impaired glucose tolerance or mild diabetes.

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for not_applicable diabetes-mellitus

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 1, 2007

Completed
Same day until next milestone

Study Start

First participant enrolled

January 1, 2007

Completed
3 days until next milestone

First Posted

Study publicly available on registry

January 4, 2007

Completed
Last Updated

January 4, 2007

Status Verified

January 1, 2007

First QC Date

January 1, 2007

Last Update Submit

January 3, 2007

Conditions

Diabetes MellitusImpaired Glucose Tolerance

Keywords

diabetesacarbosealcoholinflammationoxidative stressMild diabetes mellitus

Outcome Measures

Primary Outcomes (1)

  • Postprandial hyperglycemia

Secondary Outcomes (2)

  • Postprandial inflammatory responses

  • Postprandial oxidative stress

Interventions

AcarboseDRUG

Eligibility Criteria

Age25 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Subjects with mild diabetes without prior medications or impaired glucose tolerance

You may not qualify if:

  • Pregnancy
  • Recent major cardiac, renal and hepatic disease
  • Intolerance to alcohol
  • Allergy to acarbose treatment

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Taichung Veterans General Hospital

Taichung, Taiwan

RECRUITING

MeSH Terms

Conditions

Diabetes MellitusGlucose IntoleranceInflammation

Interventions

Acarbose

Condition Hierarchy (Ancestors)

Glucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System DiseasesHyperglycemiaPathologic ProcessesPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

TrisaccharidesOligosaccharidesPolysaccharidesCarbohydrates

Study Officials

  • Wayne H Sheu, MD, PhD

    Taichung Veterans General Hospital

    PRINCIPAL INVESTIGATOR

Central Study Contacts

I Te Lee, MD, MS

CONTACT

886-4-23592525itlee@vghtc.gov.tw

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER

Study Record Dates

First Submitted

January 1, 2007

First Posted

January 4, 2007

Study Start

January 1, 2007

Last Updated

January 4, 2007

Record last verified: 2007-01

Locations

TW(1)