Knee Malalignment and Thigh Muscle Strengthening in Individuals With Medial Knee Arthritis
The Effects of Knee Malalignment and Quadriceps Strengthening on the Adduction Moment in Individuals With Medial Knee Osteoarthritis
1 other identifier
interventional
107
1 country
1
Brief Summary
To investigate the effects of quadriceps strengthening on the adductor moment in individuals with medial knee OA and whether quadriceps strengthening has a different effect on the adductor moment in individuals with and without knee malalignment
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_2 knee-osteoarthritis
Started May 2004
Typical duration for phase_2 knee-osteoarthritis
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2004
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2006
CompletedFirst Submitted
Initial submission to the registry
December 20, 2006
CompletedFirst Posted
Study publicly available on registry
December 21, 2006
CompletedDecember 22, 2006
December 1, 2006
December 20, 2006
December 21, 2006
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Adduction moment
Time points: 0 and 13 weeks
Secondary Outcomes (7)
Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire
Numerical rating scales for pain
Quadriceps and hamstrings strength
Self-selected walking speed
Dynamic balance using step test
- +2 more secondary outcomes
Interventions
Eligibility Criteria
You may qualify if:
- Pain in the knee
- Osteophytes on knee x-ray
- Self-reported pain on the inner aspect of the study knee
- Osteophytes in the medial compartment of the knee joint and
- Medial joint space narrowing greater than lateral joint space narrowing on x-ray
You may not qualify if:
- Knee surgery within the previous 6 months
- History of lower limb joint replacements
- Systemic arthritic conditions such as rheumatic or psoriatic arthritis
- Valgus knee deformity (\> 5º)
- Inability to walk without the use of walking aids
- Intending to start a lower limb strengthening program in the next 3 months
- Seeking or currently receiving physiotherapy for OA knee
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Melbournelead
- Australian Physiotherapy Research Foundationcollaborator
- United Pacific Industriescollaborator
Study Sites (1)
The University of Melbourne
Melbourne, Victoria, 3040, Australia
Related Publications (1)
Lim BW, Hinman RS, Wrigley TV, Sharma L, Bennell KL. Does knee malalignment mediate the effects of quadriceps strengthening on knee adduction moment, pain, and function in medial knee osteoarthritis? A randomized controlled trial. Arthritis Rheum. 2008 Jul 15;59(7):943-51. doi: 10.1002/art.23823.
PMID: 18576289DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Kim Bennell, PhD
University of Melbourne
- PRINCIPAL INVESTIGATOR
Rana Hinman, PhD
University of Melbourne
- PRINCIPAL INVESTIGATOR
Tim Wrigley, MSc
University of Melbourne
- PRINCIPAL INVESTIGATOR
Boon W Lim, MSc
University of Melbourne
- PRINCIPAL INVESTIGATOR
Leena Sharma, MD
Northwestern University Medical School, Chicago
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Purpose
- TREATMENT
- Intervention Model
- FACTORIAL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
December 20, 2006
First Posted
December 21, 2006
Study Start
May 1, 2004
Study Completion
December 1, 2006
Last Updated
December 22, 2006
Record last verified: 2006-12