NCT00412672

Brief Summary

The hypothesis of the current proposal is that collateral flow is an important determinant of myocardial protection during an ischemic event. Increased collateral flow for any given area at risk will decrease the myocardial damage caused by the occlusion of the infarct related epicardial artery. It is further hypothesized that myocardial salvage provided by collateral flow will decrease infarct size and this in turn will decrease LV dilatation post-myocardial infarction.

Trial Health

10
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Status
withdrawn

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

December 15, 2006

Completed
3 days until next milestone

First Posted

Study publicly available on registry

December 18, 2006

Completed
3.5 years until next milestone

Study Start

First participant enrolled

July 1, 2010

Completed
Last Updated

June 16, 2015

Status Verified

June 1, 2015

First QC Date

December 15, 2006

Last Update Submit

June 15, 2015

Conditions

Myocardial Infarction

Keywords

Myocardial infarctioncontrast echocardiographycollateral circulation

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Patients with acute myocardial infarction undergoing primary PCI as reperfusion therapy of a totally occluded coronary artery.

You may qualify if:

  • Patients with acute myocardial infarction with electrocardiographic criterion and/or typical history of angina pectoris and planned revascularisation according to the acute myocardial infarction disease management guidelines of the University Hospital Bern. Including both, patients undergoing primary PCI and patients referred for rescue PCI after failed thrombolytic therapy
  • Patients \> 18 years old of either sex
  • Patients who have given informed consent to the study

You may not qualify if:

  • Patients unable to give informed consent e.g. because of mechanical ventilation
  • Patients with cardiogenic shock
  • Patients with myocardial infarction secondary to occlusion of a recently revascularized vessel (subacute stent thrombosis)
  • Patients with severe arrhythmias
  • Patients whose door-to-balloon time exceeds 120 minutes
  • Pregnancy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Myocardial Infarction

Condition Hierarchy (Ancestors)

Myocardial IschemiaHeart DiseasesCardiovascular DiseasesVascular DiseasesInfarctionIschemiaPathologic ProcessesPathological Conditions, Signs and SymptomsNecrosis

Study Officials

  • Christian Seiler, Prof.

    University Hospital Bern, Switzerland

    PRINCIPAL INVESTIGATOR
0

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

December 15, 2006

First Posted

December 18, 2006

Study Start

July 1, 2010

Last Updated

June 16, 2015

Record last verified: 2015-06