A Study Of GSK679586A When Infused Into Healthy And Mild Asthmatic Volunteers

NCT00411814 | Completed Phase 1

• 1 other identifier: I13105054
• Study Type: interventional
• Target: 56
• Locations: 1 country
• Sites: 2

Brief Summary

This is a two part study. Part I is designed to test single doses of GSK678586A in healthy volunteers. Part II is designed to test repeat doses (two doses) of GSK679586A in patients with mild asthma. Both parts are designed to investigate the safety, tolerability and the way the body absorbs GSK679586A when given by intravenous infusion (through a vein in your arm).

Conditions

Asthma

Keywords

melbourne,; healthy; antibody,; male,; Safety and pharmacokinetic study,; mild asthmatic patients,; australia; monoclonal; female,; volunteers,

Outcome Measures

Primary Outcomes (2)

• Safety and tolerability in healthy volunteers.Assessed using clinical safety assessments and blood and urine analysis

  Throughout the study

• Safety and tolerability in mild asthmatics.Assessed using clinical safety assessments and blood and urine analysis.

  Throughout the study

Secondary Outcomes (5)

• Blood sampling

  Throughout the study

• Effects on blood and lung function.

  Throughout the study

• Lung function

  Throughout the study

• Plasma levels of GSK679586A to determine pharmacokinetic parameters

  Throughout the study

• serum antibodies to GSK679586A

  Throughout the study

Study Arms (2)

Placebo

PLACEBO COMPARATOR

Saline

Drug: Placebo

Active

ACTIVE COMPARATOR

GSK679586

Drug: GSK679586

Interventions

GSK679586 DRUG

Active Drug

Active

Placebo DRUG

Saline

Also known as: Saline

Placebo

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Men aged 18 - 65 years inclusive, or women aged 18 - 50 years inclusive.
• Female subjects must be of non-childbearing potential,
• Male subjects must agree to abstain from sexual intercourse or use adequate contraception during sexual intercourse with pregnant or lactating females, in addition to their female partner using another form of contraception. This criterion must be followed from the time of the first dose of study medication until 84 days after the last dose of study medication.
• Body weight ≥ 50 kg and BMI within the range 19 - 29.9 kg/m2.
• Non-smoker as verified by urinary cotinine levels below 300 ng/mL at screening or ex-smokers who have given up smoking for \>12 months with a history \<10 pack years \[Pack yrs = (No of cigarettes/day x No of years smoked)/20\]
• Available to complete all study measurements.
• Able to read, comprehend, and write English at a sufficient level to complete study related materials.
• Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form
• Healthy as determined by a responsible physician, based on a medical evaluation including history, physical examination, laboratory tests, cardiac monitoring.
• History of asthma for at least 6 months prior to the screening visit currently requiring no treatment or intermittent treatment with inhaled short-acting beta2-agonist only. Subject must not have received low dose inhaled corticosteroids within three months prior to Day 0.
• Pre-bronchodilator FEV1 \>70% but \<90% of predicted at screening with ≥12% reversibility after short-acting beta2-agonist or If the subject has a pre-bronchodilator FEV1 ≥90% at screening but has a history of asthma or if the subject meets the FEV1 criteria but does not demonstrate ≥12% reversibility after short-acting beta2-agonist administration, then the subject may be considered eligible if a Bronchial Provocation Test for asthma is positive (and after consultation with Medical Monitor and Principal Investigator). The bronchial provocation will be considered positive when the standard criteria for a positive response with the given challenge agent are met.
• Skin prick test positive for an allergen that is appropriate for nasal challenge

You may not qualify if:

• As a result of medical interview, physical examination or screening investigations, the responsible physician deemed the subject unsuitable for the study.
• History of sensitivity to any of the study medications, or components thereof or a history of drug or other allergy that, in the opinion of the physician responsible, contraindicates their participation.
• Previous exposure to humanised antibody therapy for any reason.
• A strong family history of Th1 cytokine-related inflammatory disorders, including but not limited to, Type I diabetes mellitus, multiple sclerosis, Crohn's disease, rheumatoid arthritis, sarcoidosis.
• Known history of active or latent tuberculosis, or recent (within 6 months of study enrolment) exposure to a person with active tuberculosis. Previous medical history and letter from the subject's physician (GP) should exclude this.
• A history of chronic urogenital infections or other chronic infections.
• Subjects who have received any type of vaccination in the last two months.
• The subject has participated in a clinical trial and has received a drug or a new chemical entity within 30 days or 5 half-lives, or twice the duration of the biological effect of any drug(whichever is longer) prior to the first dose of current study medication
• Where participation in study would result in donation of blood in excess of 500 mL within a 56 day period
• Exposure to more than four new chemical entities within 12 months prior to the first dosing day
• Use of prescription or non-prescription drugs, including vitamins, herbal and dietary supplements (including St John'sWort) within 7 days (or 14 days if the drug is a potential enzyme inducer) or 5 half-lives (whichever is longer) prior to the first dose of study medication, unless in the opinion of the Investigator and sponsor the medication will not interfere with the study procedures or compromise subject safety.
• History of alcohol/drug abuse or dependence within 12 months of the study:
• Abuse of alcohol defined as an average weekly intake of greater than 21 units or an average daily intake of greater than 3 units (males) or defined as an average weekly intake of greater than 14 units or an average daily intake of greater than 2 units (females). 1 unit is equivalent to a half-pint (220mL) of beer or 1 (25ml) measure of spirits or 1 glass (125ml) of wine
• A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody result within 3 months of screening
• A positive test for human immunodeficiency virus (HIV) antibodies.

Sponsors & Collaborators

• GlaxoSmithKline: lead

Study Sites (2)

GSK Investigational Site

Randwick, New South Wales, 2031, Australia

Location

GSK Investigational Site

Melbourne, Victoria, 3004, Australia

Location

Related Publications (1)

• Hodsman P, Ashman C, Cahn A, De Boever E, Locantore N, Serone A, Pouliquen I. A phase 1, randomized, placebo-controlled, dose-escalation study of an anti-IL-13 monoclonal antibody in healthy subjects and mild asthmatics. Br J Clin Pharmacol. 2013 Jan;75(1):118-28. doi: 10.1111/j.1365-2125.2012.04334.x.

  PMID: 22616628 DERIVED

MeSH Terms

Conditions

Asthma

Interventions

GSK679586; Sodium Chloride

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Intervention Hierarchy (Ancestors)

Chlorides; Hydrochloric Acid; Chlorine Compounds; Inorganic Chemicals; Sodium Compounds

Study Officials

• GSK Clinical Trials

  GlaxoSmithKline

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 14, 2006
• First Posted: December 15, 2006
• Study Start: November 1, 2006
• Primary Completion: February 1, 2008
• Study Completion: February 1, 2008
• Last Updated: March 19, 2012

Record last verified: 2012-01

Locations

AU (2)