Non Alcoholic Fatty Liver Disease in Rheumatoid Arthritis

NCT00394238 | Unknown

• 1 other identifier: 20174CTIL
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Rheumatoid arthritis is a chronic inflammatory systemic disease. It has a worldwide distribution and can affect all age group. The peak incidence is between fourth and sixth decade. It is more prevalent in women, and it's prevalence in the general population in North America is between 0.2-1.5%. The etiology of RA is unknown, although clusters of the disease in families and high concordance in mono-zydotic twins support genetic predisposition. The prevalence of fatty liver disease in patients with rheumatoid arthritis is currently unknown. We wish to study the link between the two conditions by performing a son graphic imaging of the liver in a cohort of RA patients. If indeed a high prevalence of NAFLD will be found in the RA patients, further support will be landed for the link between inflammation and fatty liver disease. These findings may also have implications regarding the management and follow up of RA patients. The validity of sonographic imaging for detection of fatty liver diseases is currently accepted: On ultrasonographic, fatty infiltration of the liver produces a diffuse increase in echogenicity as compared with that of the kidneys. Ultrasonography has a sensitivity of 89% and a specificity of 93% in detecting steatosis and sensitivity and specificity of 77% and 89% respectively in detecting increase fibrosis. In view of all the above data, we expected to find higher prevalence of fatty liver in the patients with higher inflammation markers compare with patients with lower markers.

Conditions

Arthritis, Rheumatoid

Interventions

Ultrasonographic imaging PROCEDURE

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Rheumatoid arthritis

You may not qualify if:

• Age below 18

Sponsors & Collaborators

• Shaare Zedek Medical Center: lead

Study Sites (1)

Rheumatoid Clinic

Jerusalem, Israel

Location

MeSH Terms

Conditions

Arthritis, Rheumatoid

Interventions

High-Energy Shock Waves

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases

Intervention Hierarchy (Ancestors)

Ultrasonic Waves; Sound; Radiation, Nonionizing; Radiation; Physical Phenomena

Study Officials

• Michal Mates, MD

  Shaare Zedek Medical Center Jerusalem

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ornit Cohen, Msc

CONTACT

0507867234; bionet@017.net.il

Study Design

• Study Type: observational
• Observational Model: DEFINED POPULATION
• Time Perspective: OTHER
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: October 29, 2006
• First Posted: October 31, 2006
• Study Start: November 1, 2006
• Study Completion: October 1, 2008
• Last Updated: October 31, 2006

Record last verified: 2006-07

Locations

IL (1)