Effective Antibiotic Treatment of MRSA

NCT00388310 | Completed

• 1 other identifier: 26018
• Study Type: interventional
• Target: 33
• Locations: 1 country
• Sites: 1

Brief Summary

To evaluate the effective duration (in days) to clinical improvement of outpatient antibiotic regimens in the treatment of superficial abscesses caused by MRSA in patients that present to the emergency department.

Conditions

Skin Diseases, Infectious

Keywords

cellulitis; furuncles; carbuncles; abscess

Outcome Measures

Primary Outcomes (2)

• To determine the effective duration of treatment of different antibiotic regimens in the treatment of abscess with regards to resolution of patient symptoms and signs.

  5 days

• Treatment failure will be defined as an increase in patient symptoms, increase in abscess size, development of constitutional symptoms, or hospitalization secondary to abscess complications

  5 days

Study Arms (4)

Cephalexin

ACTIVE COMPARATOR

Cephalexin 250 mg PO q6h x5 days

Procedure: Culture

Clindamycin

ACTIVE COMPARATOR

Clindamycin 300 mg PO q6h x5 days

Procedure: Culture

trimethoprim/sulfamethoxazole

ACTIVE COMPARATOR

trimethoprim/sulfamethoxazole 160 mg/800 mg PO q12h x 5 days

Procedure: Culture

Placebo

PLACEBO COMPARATOR

Procedure: Culture

Interventions

Culture PROCEDURE

Culture

Cephalexin; Clindamycin; Placebo; trimethoprim/sulfamethoxazole

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• All patients age 18 and older, presenting to the emergency department with an abscess with a diameter greater than three centimeters
• Informed consent

You may not qualify if:

• Patients who are presumed to have community-acquired pathogens
• Under 18
• Abscess less than three centimeters in diameter

Sponsors & Collaborators

• Christiana Care Health Services: lead

Study Sites (1)

Christiana Care Health Services

Newark, Delaware, 19718, United States

Location

MeSH Terms

Conditions

Skin Diseases, Infectious; Cellulitis; Furunculosis; Carbuncle; Abscess

Interventions

Culture Techniques

Condition Hierarchy (Ancestors)

Infections; Skin Diseases; Skin and Connective Tissue Diseases; Suppuration; Connective Tissue Diseases; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Staphylococcal Skin Infections; Staphylococcal Infections; Gram-Positive Bacterial Infections; Bacterial Infections; Bacterial Infections and Mycoses; Skin Diseases, Bacterial; Fish Diseases; Animal Diseases

Intervention Hierarchy (Ancestors)

In Vitro Techniques; Investigative Techniques

Study Officials

• Brian Levine, MD

  Christiana Care Health Services

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 13, 2006
• First Posted: October 16, 2006
• Study Start: February 1, 2006
• Primary Completion: December 1, 2008
• Study Completion: December 1, 2008
• Last Updated: November 9, 2012

Record last verified: 2012-11

Locations

US (1)