NCT00387972

Brief Summary

GW823093 is a selective DPP-IV Inhibitor and is being investigated as a once a day oral therapy. The purpose of the Study is to evaluate the effectiveness, safety, and tolerability of 2 doses of GW823093, compared to placebo, taken once daily in patients with Type 2 diabetes mellitus.

Trial Health

30
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Timeline
Completed

Started May 2006

Typical duration for phase_2 type-2-diabetes-mellitus

Geographic Reach
1 country

57 active sites

Status
withdrawn

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2006

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

October 12, 2006

Completed
1 day until next milestone

First Posted

Study publicly available on registry

October 13, 2006

Completed
12 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2007

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2007

Completed
Last Updated

April 17, 2015

Status Verified

April 1, 2015

Enrollment Period

1.4 years

First QC Date

October 12, 2006

Last Update Submit

April 15, 2015

Conditions

Keywords

Type 2 diabetes mellitus (T2DM)glycosylated hemoglobin (HbA1c)denagliptindiabetes treatmentglycemic control

Outcome Measures

Primary Outcomes (1)

  • Change from baseline in blood glucose regulation after 26 weeks of treatment

Secondary Outcomes (1)

  • Change from baseline in glycemic parameters, insulin, body weight and waist circumference, and safety measures

Interventions

Eligibility Criteria

Age18 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Type 2 diabetes mellitus treated with diet and exercise or oral anti-diabetic treatment
  • Body mass index between 20 and 40
  • Females of childbearing potential must use adequate birth control.

You may not qualify if:

  • Subjects with previous use of insulin
  • Type 1 diabetes
  • Uncontrolled thyroid disease
  • History of drug or alcohol abuse in the past year
  • Any other clinically significant disease.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (57)

GSK Clinical Trials Call Center

Tallassee, Alabama, 36078, United States

Location

GSK Clinical Trials Call Center

Phoenix, Arizona, 85016, United States

Location

GSK Clinical Trials Call Center

Tucson, Arizona, 85710, United States

Location

GSK Clinical Trials Call Center

Beverly Hills, California, 90211, United States

Location

GSK Clinical Trials Call Center

Carmichael, California, 95608, United States

Location

GSK Clinical Trials Call Center

Concord, California, 94520-2054, United States

Location

GSK Clinical Trials Call Center

Torrance, California, 90505, United States

Location

GSK Clinical Trials Call Center

Victorville, California, 92392, United States

Location

GSK Clinical Trials Call Center

Wilmington, Delaware, 19805, United States

Location

GSK Clinical Trials Call Center

Boynton Beach, Florida, 33435, United States

Location

GSK Clinical Trials Call Center

Clearwater, Florida, 33765, United States

Location

GSK Clinical Trials Call Center

Coral Gables, Florida, 33134, United States

Location

GSK Clinical Trials Call Center

Hialeah, Florida, 33010, United States

Location

GSK Clinical Trials Call Center

Hollywood, Florida, 33023, United States

Location

GSK Clinical Trials Call Center

Melbourne, Florida, 32901, United States

Location

GSK Clinical Trials Call Center

Miami, Florida, 33169, United States

Location

GSK Clinical Trials Call Center

Opa-locka, Florida, 33054, United States

Location

GSK Clinical Trials Call Center

Plantation, Florida, 33324, United States

Location

GSK Clinical Trials Call Center

Tampa, Florida, 33609, United States

Location

GSK Clinical Trials Call Center

Calhoun, Georgia, 30701, United States

Location

GSK Clinical Trials Call Center

Roswell, Georgia, 30076, United States

Location

GSK Clinical Trials Call Center

Hayden Lake, Idaho, 83835-2108, United States

Location

GSK Clinical Trials Call Center

Chicago, Illinois, 60610, United States

Location

GSK Clinical Trials Call Center

Chicago, Illinois, 60616, United States

Location

GSK Clinical Trials Call Center

Lake Zurich, Illinois, 60047, United States

Location

GSK Clinical Trials Call Center

Watseka, Illinois, 60970, United States

Location

GSK Clinical Trials Call Center

Baton Rouge, Louisiana, 70809, United States

Location

GSK Clinical Trials Call Center

Marrero, Louisiana, 70072, United States

Location

GSK Clinical Trials Call Center

Oxon Hill, Maryland, 20745, United States

Location

GSK Clinical Trials Call Center

Detroit, Michigan, 48235, United States

Location

GSK Clinical Trials Call Center

City of Saint Peters, Missouri, 63376, United States

Location

GSK Clinical Trials Call Center

Florissant, Missouri, 63031, United States

Location

GSK Clinical Trials Call Center

St Louis, Missouri, 63128, United States

Location

GSK Clinical Trials Call Center

Las Vegas, Nevada, 89128, United States

Location

GSK Clinical Trials Call Center

Williamsville, New York, 14221, United States

Location

GSK Clinical Trials Call Center

Charlotte, North Carolina, 28277, United States

Location

GSK Clinical Trials Call Center

Morehead City, North Carolina, 28557, United States

Location

GSK Clinical Trials Call Center

Fargo, North Dakota, 58103, United States

Location

GSK Clinical Trials Call Center

Cincinnati, Ohio, 45219, United States

Location

GSK Clinical Trials Call Center

Columbus, Ohio, 43207, United States

Location

GSK Clinical Trials Call Center

Guthrie, Oklahoma, 73044, United States

Location

GSK Clinical Trials Call Center

Norman, Oklahoma, 73069, United States

Location

GSK Clinical Trials Call Center

Oklahoma City, Oklahoma, 73112-5550, United States

Location

GSK Clinical Trials Call Center

Oklahoma City, Oklahoma, 73116, United States

Location

GSK Clinical Trials Call Center

Yukon, Oklahoma, 73112, United States

Location

GSK Clinical Trials Call Center

Eugene, Oregon, 97404, United States

Location

GSK Clinical Trials Call Center

Medford, Oregon, 97504, United States

Location

GSK Clinical Trials Call Center

Beaver Falls, Pennsylvania, 15010, United States

Location

GSK Clinical Trials Call Center

Fleetwood, Pennsylvania, 19522, United States

Location

GSK Clinical Trials Call Center

Warminster, Pennsylvania, 18974, United States

Location

GSK Clinical Trials Call Center

Anderson, South Carolina, 29621, United States

Location

GSK Clinical Trials Call Center

Chattanooga, Tennessee, 37404, United States

Location

GSK Clinical Trials Call Center

Johnson City, Tennessee, 37601, United States

Location

GSK Clinical Trials Call Center

Cleburne, Texas, 76033, United States

Location

GSK Clinical Trials Call Center

San Antonio, Texas, 78205, United States

Location

GSK Clinical Trials Call Center

Seguin, Texas, 78155, United States

Location

GSK Clinical Trials Call Center

Weber City, Virginia, 24290, United States

Location

MeSH Terms

Conditions

Diabetes Mellitus, Type 2

Interventions

denagliptin

Condition Hierarchy (Ancestors)

Diabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Study Officials

  • GSK Clinical Trial, DM, FRCP

    GlaxoSmithKline

    STUDY DIRECTOR
0

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
DOUBLE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

October 12, 2006

First Posted

October 13, 2006

Study Start

May 1, 2006

Primary Completion

October 1, 2007

Study Completion

October 1, 2007

Last Updated

April 17, 2015

Record last verified: 2015-04

Locations