Family Atherosclerosis Counseling and Testing Project
1 other identifier
observational
N/A
0 countries
N/A
Brief Summary
Family history of early atherosclerotic disease in a first-degree relative \[(FDR) sibling, parent or child\] is an important risk factor for coronary artery and/or vascular disease. The risk increases \~ 2 - 7 times over that of general population. Increased thickness of the intima and media of carotid arterial wall, increased rate of plaque formation is an independent predictor of cardiovascular disease. Also it is shown that increased level of calcium deposition in the arterial wall is also associated with increased level of coronary artery narrowing. We will assess the occurrence and severity of abnormalities of intima media thickness (IMT) and/or plaque formation and increased calcium deposition in the coronary arteries and their relation to the well known traditional risk factors (plasma glucose, smoking, BMI, waist circumference, blood pressure, total cholesterol, low density lipoprotein, total cholesterol/high density lipoprotein ratio) and non-traditional risk factors (C-reactive protein, Lpa, homocysteine) in FDRs of index patients with early onset of heart or vascular disease and appropriate control population. Also to determine which of the above factor can assess IMT and Ca score better. This may help to reduce the cost of investigation, and to identify the population at high risk of developing cardiovascular disease, which may help the physicians to treat early on before cardiovascular complications occur. Also this may help to reduce the cost of invasive tests, hospital admissions and medical costs overall by reducing the morbidity and mortality.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
Started Feb 2003
Typical duration for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2003
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2006
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2006
CompletedFirst Submitted
Initial submission to the registry
October 11, 2006
CompletedFirst Posted
Study publicly available on registry
October 13, 2006
CompletedAugust 8, 2008
August 1, 2008
3.7 years
October 11, 2006
August 6, 2008
Conditions
Keywords
Eligibility Criteria
You may qualify if:
- First degree relatives of patients with early onset of cardiovascular disease (men\<50 and women\<60 years of age).
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Taraboanta C, Hague CJ, Mancini GB, Forster BB, Frohlich J. Coronary artery calcium findings in asymptomatic subjects with family history of premature coronary artery disease. BMC Cardiovasc Disord. 2012 Jul 17;12:53. doi: 10.1186/1471-2261-12-53.
PMID: 22805651DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jiri Frohlich
University of British Columbia
Study Design
- Study Type
- observational
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
October 11, 2006
First Posted
October 13, 2006
Study Start
February 1, 2003
Primary Completion
October 1, 2006
Study Completion
October 1, 2006
Last Updated
August 8, 2008
Record last verified: 2008-08