To Compare the Ischemic Pre-conditioning and Post-conditioning on Reperfusion Injury in Humans.

NCT00385151 | Completed

• 1 other identifier: 0920-2004
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Reperfusion Injury occurs by the sudden blood flow to the injured and ischemic myocardium during restoration of blood flow either by Mechanical revascularization or thrombolysis. A phenomenon known as Pre-conditioning has been identified to limit the the extent and severity of reperfusion injury but it is very difficult to apply it in patient care setting as timing of acute cardiac or neurologic ischemic event is difficult to reliably predict. Postconditioning or ischemic postconditioning is well known to attenuate the reperfusion injury. There is enough data that shows the benefit of post conditioning in reducing the reperfusion injury in animals. However postconditioning in humans has not been investigated. We hypothesize that Post conditioning will attenuate the reperfusion injury and will be comparable to the effect of preconditioning in humans.

Conditions

Endothelial Dysfunction

Keywords

Post conditioning

Eligibility Criteria

• Age: 15 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Male and female volunteers between the ages of 18 and 35.
• Able to give informed and witnessed consent.
• Don't have the following risk factor
• Non smoker
• LDL\<180, HDL\>30, TG\<200 or LDL/HDL\<6.0
• Does not have diabetes mellitus .
• BP \< 135/85
• Do not have family history defined as a parent or sibling with coronary disease diagnosed before age 40. .

You may not qualify if:

• Patients with significant medial illness for which they are receiving continued monitoring or treatment, known cardiovascular disease, or risk factors for coronary artery disease are excluded. These risk factors include
• Smoking
• Hyperlipidemia defined as and LDL\>180, HDL\<30, TG\>200 or LDL/HDL\>6.0
• Diabetes mellitus
• Hypertension,
• Strong family history defined as a parent or sibling with coronary disease diagnosed before age 40.

Sponsors & Collaborators

• Emory University: lead

Study Sites (1)

Emory University Hospital

Atlanta, Georgia, 30322, United States

Location

Study Officials

• Tarek Helmy, MD

  Emory University

  PRINCIPAL INVESTIGATOR

• Arshed Ali Quyyumi, MD

  Emory University

  PRINCIPAL INVESTIGATOR

• Muhammad Amer, MD

  Emory University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 3, 2006
• First Posted: October 6, 2006
• Study Start: May 1, 2006
• Study Completion: August 1, 2006
• Last Updated: November 18, 2013

Record last verified: 2013-11

Locations

US (1)