Prevalence of Chronic KIdney Disease in Hypertensive Patients

NCT00383968 | Unknown

• 1 other identifier: 06GS009CHS
• Study Type: observational
• Target: 248
• Locations: 1 country
• Sites: 1

Brief Summary

Prevention of progressive renal disease needs a clear understanding of prevalence of early stage of chronic kidney disease in a community. Even in developed countries most subjects in early stages of chronic kidney disease go largely undiagnosed and untreated. Targeted screening could identify a greater numbers of individuals at risk then a general public screening (11). It is economically more feasible to perform in a country like Pakistan. Hypertension and diabetes are highly prevalent in South-Asia.It is anticipated that if target screening of hypertensive population is performed especially of an age group in which intervention might be expected to have maximal benefit it will not only help to identify from a large number of patients with essential hypertension destined to develop or in the course of advancing towards end stage renal disease but will also unearth mislabeled "essential hypertension" that have underlying primary renal disease. This later group may belong to socio-economic disadvantaged population who have limited access to health care and have never been investigated properly. The aim of the Study is to detect sub-clinical chronic kidney disease in hypertensive patients at community level and to identify associated risk factors.

Conditions

Hypertension; Chronic Kidney Disease

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Known hypertensives aged 40 and above with microalbuminuria and/or elevated serum creatinine on first evaluation.
• Hypertension: Systolic blood pressure ≥140, and /or diastolic blood pressure ≥ 90 with or without antihypertensive drugs.
• Microalbuminuria:
• Albumin concentration of 20-200mg/L, with albumin-to-creatinine ratio of 3-30mg/mmol or 30-300mg/g
• Female: 3.0-30.0mg/mmol or 30-300mg/g
• Male: 2.0-20.0mg/mmol or 20
• Elevated Serum creatinine:
• Female: \>1.2mg/dl
• Male: \>1.4mg/dl

You may not qualify if:

• Known diabetics will be excluded.
• unable to give informed consent

Sponsors & Collaborators

• Aga Khan University: lead

Study Sites (1)

Aga Khan University

Karachi, Sindh, Pakistan

RECRUITING

MeSH Terms

Conditions

Hypertension; Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Tazeen H Jafar, MD, MPH

  Aga Khan University

  STUDY DIRECTOR

• Muslima A Ejaz, MBBS

  Aga Khan University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Muslima Ejaz A Ejaz, MBBS

CONTACT

4864860; muslima.ejaz@aku.edu

Tazeen H Jafar, MD,MPH

CONTACT

4930051; tazeen.jafar@aku.edu

Study Design

• Study Type: observational
• Observational Model: DEFINED POPULATION
• Time Perspective: OTHER
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: October 3, 2006
• First Posted: October 4, 2006
• Study Start: October 1, 2006
• Study Completion: December 1, 2006
• Last Updated: October 4, 2006

Record last verified: 2006-10

Locations

PA (1)