NCT00382369

Brief Summary

Vocal cord paralysis is a common cause of congenital stridor and airway obstruction. In this study we plan to identify the genetic locus of the genes in two extended families who suffer of the disease.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
11

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Jun 2008

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

September 28, 2006

Completed
1 day until next milestone

First Posted

Study publicly available on registry

September 29, 2006

Completed
1.7 years until next milestone

Study Start

First participant enrolled

June 1, 2008

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 17, 2008

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

December 29, 2008

Completed
Last Updated

February 27, 2017

Status Verified

February 1, 2017

Enrollment Period

6 months

First QC Date

September 28, 2006

Last Update Submit

February 23, 2017

Conditions

Vocal Cord Paralysis

Keywords

familial vocal cord paralysisgenetic screening

Eligibility Criteria

Age10 Years+
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Families suffering of familial vocal cord paralysis

You may qualify if:

  • members of families suffering of familial vocal cord paralysis

You may not qualify if:

  • none

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Hadassah-Hebrew University Medical Center, Mt Scopus

Jerusalem, 24035, Israel

Location

Related Publications (1)

  • Manaligod JM, Skaggs J, Smith RJ. Localization of the gene for familial laryngeal abductor paralysis to chromosome 6q16. Arch Otolaryngol Head Neck Surg. 2001 Aug;127(8):913-7. doi: 10.1001/archotol.127.8.913.

    PMID: 11493198BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

DNA prepared from blood

MeSH Terms

Conditions

Vocal Cord Paralysis

Condition Hierarchy (Ancestors)

Laryngeal DiseasesRespiratory Tract DiseasesOtorhinolaryngologic DiseasesVagus Nerve DiseasesCranial Nerve DiseasesNervous System DiseasesParalysisNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Eitan Kerem, MD

    Hadassah MO

    STUDY DIRECTOR

  • Batsheva Kerem, PhD

    Hebrew University Jerusalem

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
FAMILY BASED
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

September 28, 2006

First Posted

September 29, 2006

Study Start

June 1, 2008

Primary Completion

November 17, 2008

Study Completion

December 29, 2008

Last Updated

February 27, 2017

Record last verified: 2017-02

Data Sharing

IPD Sharing
Will not share

Locations

IL(1)