Understanding the Genetic Basis of Atherosclerosis and Peripheral Arterial Disease
GenePAD
The Genetic Determinants of Peripheral Arterial Disease
2 other identifiers
observational
1,789
1 country
2
Brief Summary
Atherosclerosis, a condition in which fatty deposits build up along the inner walls of arteries, can occur throughout the body. The purpose of this study is to examine the possible genetic differences that may influence where atherosclerosis occurs.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2004
CompletedFirst Submitted
Initial submission to the registry
September 22, 2006
CompletedFirst Posted
Study publicly available on registry
September 25, 2006
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2008
CompletedMay 28, 2015
May 1, 2015
4.3 years
September 22, 2006
May 27, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Identifying genetic variations that may cause inherited differences in plaque distribution
Measured at participants' study visit
Study Arms (3)
1
Subjects with no hemodynamically significant disease (NHSD) of the coronary or peripheral arteries
2
Subjects with coronary artery disease only
3
Subjects with both coronary artery disease and peripheral arterial disease
Eligibility Criteria
Subjects are recruited from individuals undergoing elective coronary angiography for suspected CAD at Stanford University or Mount Sinai Medical Centers.
You may qualify if:
- Hemodynamically significant PAD, as documented by an ankle-brachial index less than 0.9; control group participants will not have PAD
- Received a referral for an elective coronary angiogram
- Suspected CAD
You may not qualify if:
- History of radiation treatment
- History of organ transplant
- History of viral diseases (i.e. HIV, hepatitis)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Stanford University
Stanford, California, 94305, United States
Mt. Sinai Medical Center
New York, New York, 10029, United States
Related Publications (2)
Flores AM, Schuler A, Eberhard AV, Olin JW, Cooke JP, Leeper NJ, Shah NH, Ross EG. Unsupervised Learning for Automated Detection of Coronary Artery Disease Subgroups. J Am Heart Assoc. 2021 Dec 7;10(23):e021976. doi: 10.1161/JAHA.121.021976. Epub 2021 Nov 30.
PMID: 34845917DERIVEDSadrzadeh Rafie AH, Stefanick ML, Sims ST, Phan T, Higgins M, Gabriel A, Assimes T, Narasimhan B, Nead KT, Myers J, Olin J, Cooke JP. Sex differences in the prevalence of peripheral artery disease in patients undergoing coronary catheterization. Vasc Med. 2010 Dec;15(6):443-50. doi: 10.1177/1358863X10388345.
PMID: 21183651DERIVED
Biospecimen
Serum, Plasma, White Cells
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
John P. Cooke, MD, PhD
Stanford University
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor of Medicine
Study Record Dates
First Submitted
September 22, 2006
First Posted
September 25, 2006
Study Start
April 1, 2004
Primary Completion
July 1, 2008
Last Updated
May 28, 2015
Record last verified: 2015-05