Bortezomib and CHOP in Patients With Advanced Stage Aggressive T Cell or Natural Killer (NK)/T Cell Lymphomas

NCT00374699 | Completed Phase 1

• 1 other identifier: 2005-07-021
• Study Type: interventional
• Target: 55
• Locations: 1 country
• Sites: 1

Brief Summary

Peripheral T-cell lymphomas (PTCLs) are neoplasias from post-thymic T-cells at different stages of differentiation and are a heterogeneous group of malignancies which present with different morphological patterns, phenotypes, and clinical presentations. These tumours have a striking epidemiological distribution with a lower incidence in Western countries than in Asia. In Korea, PTCLs including T- or natural killer (NK)-cell lymphomas constitute approximately 25 to 35% of all non-Hodgkin's lymphomas. This incidence is quite similar to that of other Eastern Asian countries, including Japan, Hong Kong, and China. Recent studies suggest that the T-cell phenotype is an independent significant prognostic factor, with PTCLs having one of the lowest overall survival and failure-free survival rates. Based on the investigator's experience, the overall complete remission rate was 61.2% (95% confidence interval \[CI\]: 48.5-72.8%) and the 5-year probability of failure-free survival was 33.5%. Median survival of all patients was 45 months (range 0-64+ months) and the 5-year probability of survival was 36.2%. Rassidakis et al. reported that expression of pro-apoptotic proteins BAX and BCL-XS, may explain the poor response of many types of PTCL to standard chemotherapy. To overcome such poor outcome, the optimal therapy for PTCLs remains to be defined. However, because of the rarity of the disease in Western countries, only a few trials have been reported. Bortezomib (Velcade) is a modified dipeptidyl boronic acid, and a reversible inhibitor of the chymotrypsin-like activity of the 26S proteosome. Bortezomib may induce tumor cell apoptosis or decreased bcl-2 associated drug resistance. Through phase II studies, single agent bortezomib in patients with relapsed indolent and mantle cell lymphomas showed its activity. And also preliminary data indicate that bortezomib can be safely administered in combination with dose adjusted etoposide, prednisolone, vincristine, cyclophosphamide and doxorubicin (EPOCH) chemotherapy. Therefore, it can be possible to improve the poor outcome of patients with PTCLs by a combination of cyclophosphamide, doxorubicin, vincristine, prednisolone (CHOP) with bortezomib as a first-line therapy. Primary Hypothesis: Based on the clinical trials and experimental data, bortezomib can overcome pro-apoptotic proteins BAX and BCL-XS induced drug resistance.

Conditions

Peripheral T-Cell Lymphomas; Non-Hodgkin Lymphoma

Keywords

Velcade; Bortezomib; CHOP; Peripheral T-cell lymphomas(PTCLs); natural killer (NK)-cell lymphomas

Outcome Measures

Primary Outcomes (2)

• To define the dose-limiting toxicity and maximum tolerable dose

  Phase I

• To evaluate the overall response rate

  Phase II

Secondary Outcomes (2)

• To evaluate the safety and tolerability of the treatment combination

  Phase I/II

• To estimate the time to progression and the duration of overall response

  Phase II

Interventions

Velcade DRUG

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Histologically confirmed PTCLs and NK/T cell lymphomas excluding anaplastic lymphoma kinase (ALK)-positive anaplastic large cell T-cell lymphomas (ALCL)
• Performance status (ECOG) ≤ 3
• Age ≤ 65
• At least one or more unidimensionally measurable lesion(s)
• ≥ 2 cm by conventional computed tomography (CT)
• ≥ 1 cm by spiral CT
• skin lesion (photographs should be taken)
• measurable lesion by physical examination
• Laboratory values
• Creatinine (Cr) \< 1.5 mg% or creatinine clearance (Ccr) \> 50 ml/min
• Transaminase \< 3 X upper normal value
• Bilirubin \< 2.0 mg/dl
• Absolute neutrophil count (ANC) \> 1,500/ul
• Platelets \> 75,000/ul
• Informed consent

You may not qualify if:

• Any other malignancies within the past 5 years except basal cell skin cancer or carcinoma in situ (CIS) of the cervix
• Serious comorbid diseases
• Pregnancy or breast feeding

Sponsors & Collaborators

• Samsung Medical Center: lead
• Janssen Medical Affairs: collaborator

Study Sites (1)

Samsung Medical Center

Seoul, Seoul, 135-710, South Korea

Location

MeSH Terms

Conditions

Lymphoma, T-Cell, Peripheral; Lymphoma, Non-Hodgkin

Interventions

Bortezomib

Condition Hierarchy (Ancestors)

Lymphoma, T-Cell; Lymphoma; Neoplasms by Histologic Type; Neoplasms; Lymphoproliferative Disorders; Lymphatic Diseases; Hemic and Lymphatic Diseases; Immunoproliferative Disorders; Immune System Diseases

Intervention Hierarchy (Ancestors)

Boronic Acids; Acids, Noncarboxylic; Acids; Inorganic Chemicals; Boron Compounds; Organic Chemicals; Pyrazines; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds

Study Officials

• Won Seog Kim, MD, PhD

  Samsung Medical Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: September 7, 2006
• First Posted: September 11, 2006
• Study Start: April 1, 2006
• Primary Completion: September 1, 2009
• Study Completion: October 1, 2009
• Last Updated: October 14, 2009

Record last verified: 2007-06

Locations

KR (1)