Study of the Relationship Between Blood Vessels and Insulin Response in Adolescents

NCT00374361 | Completed

• 2 other identifiers: ENDO 203AHA 0355195B
• Study Type: observational
• Target: 66
• Locations: 1 country
• Sites: 1

Brief Summary

This study is designed to determine whether there is a relationship between the way insulin and blood vessels work. The difference in the interaction between Caucasian and African American adolescents will also be examined. This may play a role in the differing rates of heart disease and diabetes between the two groups.

Conditions

Diabetes Mellitus, Type 2; Hypertension; Heart Disease; Stroke

Keywords

insulin sensitivity; endothelial function; adolescence; lipids; puberty

Study Arms (2)

Caucasian Adolescents

Caucasian Adolescents

African-American Adolescents

African-American Adolescents

Eligibility Criteria

• Age: 8 Years - 18 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Adolescents

You may qualify if:

• Caucasian or African American adolescent
• Between 8 and 18 years of age

You may not qualify if:

• Pregnancy
• Chronic Disease
• Acute Disease
• Medication Requirement

Sponsors & Collaborators

• Ohio State University: lead
• Nationwide Children's Hospital: collaborator

Study Sites (1)

Ohio State University

Columbus, Ohio, 43210, United States

Location

Related Publications (4)

• Hoffman RP. Indices of insulin action calculated from fasting glucose and insulin reflect hepatic, not peripheral, insulin sensitivity in African-American and Caucasian adolescents. Pediatr Diabetes. 2008 Jun;9(3 Pt 2):57-61. doi: 10.1111/j.1399-5448.2007.00350.x. Epub 2008 Jan 21.

  PMID: 18221434 RESULT

• Duck MM, Hoffman RP. Impaired endothelial function in healthy African-American adolescents compared with Caucasians. J Pediatr. 2007 Apr;150(4):400-6. doi: 10.1016/j.jpeds.2006.12.034.

  PMID: 17382119 RESULT

• Hoffman RP. Increased fasting triglyceride levels are associated with hepatic insulin resistance in Caucasian but not African-American adolescents. Diabetes Care. 2006 Jun;29(6):1402-4. doi: 10.2337/dc06-2460. No abstract available.

  PMID: 16732033 RESULT

• Xie L, Hoffman RP, Veng-Pedersen P. Noncompartmental pharmacokinetics analysis of glucose-stimulated insulin response in African-American and Caucasian youths. Biopharm Drug Dispos. 2009 Apr;30(3):117-25. doi: 10.1002/bdd.652.

  PMID: 19288584 RESULT

MeSH Terms

Conditions

Diabetes Mellitus, Type 2; Hypertension; Heart Diseases; Stroke; Insulin Resistance

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Vascular Diseases; Cardiovascular Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Hyperinsulinism

Study Officials

• Robert P Hoffman, MD

  Ohio State University

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: September 7, 2006
• First Posted: September 11, 2006
• Study Start: July 1, 2003
• Primary Completion: June 1, 2006
• Study Completion: June 1, 2006
• Last Updated: June 8, 2016

Record last verified: 2016-06

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)