Trials Sponsors Conditions Drugs Pricing

Conditions

Marijuana Use Disorder

Keywords

CannabinoidsRisk takingDecision making

Outcome Measures

Primary Outcomes (1)

Change From Baseline in Iowa Gambling Task Scores [Objective Measure of Decision Making]
A modified version of the Gambling Task (Bechara et al., 1994) was used. Four decks of cards (A-D) were displayed on a computer screen. Volunteers were told that the objective of the game was to win as much money as possible. They were also told that the game entailed a series of card selections from any of the decks, one card at a time, and that they should select cards until instructed to stop. The task was stopped after 100 card selections or after 5 min had elapsed. Data indicate change from baseline in mean number of cards selected from advantageous decks minus number of cards selected from disadvantageous decks as a function of drug condition. Higher numbers indicate better decision making regarding advantageous cards. Planned comparisons using single degrees of freedom, generated by a two-tailed repeated measures analysis of variance (ANOVA), were used to examine the effects of THC concentration (0% vs. 1.8%, 0% vs. 3.9%, and 1.8% vs. 3.9%) on task performance.
3 weeks

Study Arms (2)

Inactive Marijuana (0, 1.8, or 3.9% THC)

PLACEBO COMPARATOR

In this randomized, placebo-controlled study, every participant received all 3 treatment interventions in randomized order. Inactive marijuana (0% THC) served as a placebo comparator. Participants received an inactive marijuana cigarette (0% THC; provided by NIDA) in 1 of the 3 outpatient sessions in randomized order.

Drug: Inactive Marijuana (0% THC)

Active Marijuana

EXPERIMENTAL

In this randomized, placebo-controlled study, every participant received all 3 treatment interventions in randomized order. Participants received active marijuana cigarettes (1.8, or 3.9% THC; provided by NIDA) over 2 of 3 outpatient sessions in randomized order.

Drug: Low THC marijuana (1.8 %THC)Drug: High THC marijuana (3.9% THC)

Interventions

Inactive Marijuana (0% THC)Drug

Placebo marijuana was administered using a cued-smoking procedure, which produces reliable increases in heart-rate and plasma THC. All marijuana cigarettes were administered in a double-blind fashion.

Also known as: placebo marijuana

Inactive Marijuana (0, 1.8, or 3.9% THC)

Low THC marijuana (1.8 %THC)Drug

Active marijuana (1.8 % THC) was administered using a cued-smoking procedure, which produces reliable increases in heart-rate and plasma THC. All marijuana cigarettes were administered in a double-blind fashion.

Eligibility Criteria

Age21 Years - 45 Years

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64)

You may qualify if:

Current marijuana use
years of age

Sponsors & Collaborators

New York State Psychiatric Institute
Otherlead
National Institute on Drug Abuse (NIDA)
NIHcollaborator

Study Sites (1)

New York State Psychiatric Institute

New York, New York, 10032, United States

MeSH Terms

Conditions

Risk-Taking

Interventions

Dronabinolnabiximols

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

CannabinoidsTerpenesHydrocarbonsOrganic Chemicals

Results Point of Contact

Title: Margaret Haney
Organization: New York State Psychiatric Institute

Study Officials

Margaret Haney, Ph.D.
New York State Psychiatric Institute
PRINCIPAL INVESTIGATOR
Efrat Aharonovich, Ph.D.
New York State Psyhciatric Institute
PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee: No
Restrictive Agreement: No

Enrollment

36 participants (actual enrollment reported by the registry).

Study Design

Study Type: interventional
Phase: phase 1
Allocation: RANDOMIZED
Masking: DOUBLE
Who Masked: PARTICIPANT, INVESTIGATOR
Masking Details: Double-blind, placebo-controlled
Purpose: BASIC SCIENCE
Intervention Model: CROSSOVER
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Associate Professor of Clinical Psychology (in Psychiatry)

Study Record Dates

First Submitted

September 7, 2006

First Posted

September 8, 2006

Study Start

May 2006

Date type not reported

Effects of Smoked Marijuana on Risk Taking and Decision Making Tasks

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Results Posted

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Study Arms (2)

Inactive Marijuana (0, 1.8, or 3.9% THC)

Active Marijuana

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Intervention Hierarchy (Ancestors)

Results Point of Contact

Study Officials

Publication Agreements

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Results Posted

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Study Arms (2)

Inactive Marijuana (0, 1.8, or 3.9% THC)

Active Marijuana

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Intervention Hierarchy (Ancestors)

Results Point of Contact

Study Officials

Publication Agreements

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations