NCT00372814

Brief Summary

The study is a randomized clinical trial testing the effectiveness of Multisystemic Therapy (MST) for improving the treatment adherence, metabolic control and quality of life of urban adolescents with poorly controlled insulin dependent diabetes.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
146

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Mar 2007

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

September 5, 2006

Completed
2 days until next milestone

First Posted

Study publicly available on registry

September 7, 2006

Completed
6 months until next milestone

Study Start

First participant enrolled

March 1, 2007

Completed
3.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2011

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2011

Completed
Last Updated

June 2, 2017

Status Verified

June 1, 2017

Enrollment Period

3.8 years

First QC Date

September 5, 2006

Last Update Submit

June 1, 2017

Conditions

Keywords

diabetesregimen adherencemetabolic controladolescentsfamily therapy

Outcome Measures

Primary Outcomes (1)

  • Metabolic Control: Hemoglobin A1c (HbA1c)

    Retrospective measure of blood glucose control, encompasses the previous 2-3 months

    treatment termination, 6-month follow up

Secondary Outcomes (4)

  • BMI percentile

    treatment termination, 6-month follow up

  • Diabetes-Specific Family Functioning

    treatment termination, 6-month follow up

  • DKA admissions and emergency room (ER) Visits: hospital information systems data extraction, Service Utilization Questionnaire (SUQ)

    treatment termination, 6-month follow up

  • Regimen Adherence: Diabetes Management Scale (DMS), Twenty-Four Hour Recall Interview, Glucose Meter Downloads

    treatment termination, 6-month follow up

Study Arms (2)

Multisystemic Therapy (MST)

EXPERIMENTAL

Adolescents receiving MST will receive Intensive Home-Based Family Therapy which will consist of home-based, family psychotherapy sessions 2-3 times a week, lasting 60 minutes in duration from a pediatric mental health worker for six months. The purpose of the therapy sessions are to improve the youths' ability to complete their daily diabetes illness management tasks, reduce average blood glucose levels and improve metabolic control.

Behavioral: Intensive Home-Based Family Therapy

Telephone Support Calls

ACTIVE COMPARATOR

Adolescents receiving Supportive Telephone Calls (TS) will receive weekly 30 minute phone calls from a pediatric mental health worker for six months. The purpose of the call is to provide emotional support regarding the adolescent's chronic medical condition, assess adherence to the prescribed regimen and to help the adolescent brainstorm solutions to any barriers they identify to completion of diabetes care.

Behavioral: Supportive Telephone Calls

Interventions

Multisystemic Therapy (MST): Adolescents receiving MST will receive home-based, family psychotherapy sessions 2-3 times a week, lasting 60 minutes in duration from a pediatric mental health worker for six months. The purpose of the therapy sessions are to improve the youths' ability to complete their dilay diabetes illness management tasks, reduce average blood glucose levels and improve metabolic control.

Also known as: Multisystemic Therapy, MST
Multisystemic Therapy (MST)

Telephone Support Calls: Adolescents receiving TS will receive weekly 30 minute phone calls from a pediatric mental health worker for six months. The purpose of the call is to provide emotional support regarding the adolescent's chronic medical condition, assess adherence to the prescribed regimen and to help the adolescent brainstorm solutions to any barriers they identify to completion of diabetes care.

Also known as: TS
Telephone Support Calls

Eligibility Criteria

Age10 Years - 17 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • insulin dependent Type 1 or Type 2 diabetes
  • diagnosed with diabetes ≥ 1 year
  • current HbA1c ≥ 8%
  • average HbA1c ≥ 8% over the past year
  • aged 10 -17
  • patient of Children's Hospital of Michigan Diabetes Clinic
  • lives within 30 miles of Children's Hospital of Michigan

You may not qualify if:

  • moderate to severe mental retardation (unable to complete study measures)
  • psychosis or current suicidal intent
  • any medical diagnosis that alters standard diabetes care

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Children's Hospital of Michigan

Detroit, Michigan, 48201, United States

Location

Related Publications (2)

  • Ellis DA, Naar-King S, Chen X, Moltz K, Cunningham PB, Idalski-Carcone A. Multisystemic therapy compared to telephone support for youth with poorly controlled diabetes: findings from a randomized controlled trial. Ann Behav Med. 2012 Oct;44(2):207-15. doi: 10.1007/s12160-012-9378-1.

  • Carcone AI, Ellis DA, Chen X, Naar S, Cunningham PB, Moltz K. Multisystemic Therapy Improves the Patient-Provider Relationship in Families of Adolescents with Poorly Controlled Insulin Dependent Diabetes. J Clin Psychol Med Settings. 2015 Sep;22(2-3):169-78. doi: 10.1007/s10880-015-9422-y.

MeSH Terms

Conditions

Diabetes Mellitus, Type 1Diabetes Mellitus

Condition Hierarchy (Ancestors)

Glucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System DiseasesAutoimmune DiseasesImmune System Diseases

Study Officials

  • Deborah A. Ellis, Ph.D.

    Wayne State University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor of Pediatrics

Study Record Dates

First Submitted

September 5, 2006

First Posted

September 7, 2006

Study Start

March 1, 2007

Primary Completion

January 1, 2011

Study Completion

January 1, 2011

Last Updated

June 2, 2017

Record last verified: 2017-06

Data Sharing

IPD Sharing
Will not share

Locations