NCT00370123

Brief Summary

Endometriosis is a chronic disabling inflammatory disease which effects 15-20% of women in their reproductive life. In patients suffering from endometriosis retrograded menstrual cells induce an inflammatory response.Endometriosis has also been considered to be an autoimmune disease, owing to the presence of auto antibodies, the association with other autoimmune diseases and recurrent immune-mediated abortion. We aim to study this aberrant regulation of endometrial cell apoptosis by investigating the peripheral blood immune system of patients suffering from endometriosis. Hypothesis: We hypothesized that immune peripheral mononuclear cells of patients suffering from pelvic endometriosis react differently to eutopic endometrial cells than matched control women group. This difference could be study on a molecular, antigenic and/or apoptotic cycle gene expression. We also hypothesized that a deficiency of regulatory T cells is associated with the progression of endometriosis.

Trial Health

10
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
50

participants targeted

Target at P25-P50 for all trials

Status
withdrawn

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 29, 2006

Completed
1 day until next milestone

First Posted

Study publicly available on registry

August 30, 2006

Completed
2 days until next milestone

Study Start

First participant enrolled

September 1, 2006

Completed
Last Updated

June 28, 2011

Status Verified

June 1, 2011

First QC Date

August 29, 2006

Last Update Submit

June 26, 2011

Conditions

Endometriosis

Keywords

endometriosisapoptosisregulatory T cells

Eligibility Criteria

Age18 Years - 45 Years
Sexfemale
Healthy VolunteersYes
Age GroupsAdult (18-64)
Sampling MethodNon-Probability Sample
Study Population

women of childbrearing age suffering from endometriosis and undergoing laparoscopy

You may qualify if:

  • laparoscopically proven endometriosis

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Endometriosis

Condition Hierarchy (Ancestors)

Genital Diseases, FemaleFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesGenital Diseases

Study Officials

  • Mati Mandel, MD

    Sheba Medical Center

    STUDY CHAIR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER GOV

Study Record Dates

First Submitted

August 29, 2006

First Posted

August 30, 2006

Study Start

September 1, 2006

Last Updated

June 28, 2011

Record last verified: 2011-06