NCT00367887

Brief Summary

This is a phase 2, randomized, open-label study comparing the safety, antiviral activity, and pharmacokinetics of HCV-796 administered in combination with peginterferon alfa 2B (Peg-Intron) plus concomitant Rebetol vs. Peg-Intron plus Rebetol in Hepatitis C Virus (HCV) genotype 1-infected subjects who are either naive to treatment or who have previously failed treatment (non-responders).

Trial Health

90
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
246

participants targeted

Target at P75+ for phase_2

Timeline
Completed

Started Oct 2006

Geographic Reach
2 countries

35 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 21, 2006

Completed
2 days until next milestone

First Posted

Study publicly available on registry

August 23, 2006

Completed
1 month until next milestone

Study Start

First participant enrolled

October 1, 2006

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2008

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2008

Completed
Last Updated

February 11, 2013

Status Verified

February 1, 2013

Enrollment Period

1.8 years

First QC Date

August 21, 2006

Last Update Submit

February 7, 2013

Conditions

Keywords

Hepatitis C

Outcome Measures

Primary Outcomes (1)

  • Hepatitis C Virus (HCV) RNA concentrations in the blood.

    72 weeks

Study Arms (3)

1

ACTIVE COMPARATOR
Drug: Peg-IntronDrug: REBETOL

2

ACTIVE COMPARATOR
Drug: HCV 796Drug: Peg-IntronDrug: REBETOL

3

ACTIVE COMPARATOR
Drug: HCV 796Drug: Peg-IntronDrug: REBETOL

Interventions

SC injection, weight based dosing, weekly, 48 weeks

1

Capsules, weight based dosing, Q12 hrs daily, 48weeks

1

Capsules, 500 mg, Q 12 hrs. daily, 48 weeks

2

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Infection with HCV genotype 1.
  • HCV- infected subjects naive to treatment.
  • HCV-infected non-responder subjects.

You may not qualify if:

  • Women who are pregnant or breastfeeding.
  • ALT \>/ or = 5X the upper limit of normal.
  • AST \>/ or = 5X the upper limit of normal.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (35)

Pfizer Investigational Site

Anaheim, California, 92801, United States

Location

Pfizer Investigational Site

La Jolla, California, 92037, United States

Location

Pfizer Investigational Site

La Jolla, California, 92067, United States

Location

Pfizer Investigational Site

Los Angeles, California, 90033, United States

Location

Pfizer Investigational Site

Pasadena, California, 91105, United States

Location

Pfizer Investigational Site

San Diego, California, 92123, United States

Location

Pfizer Investigational Site

San Diego, California, 92161, United States

Location

Pfizer Investigational Site

San Francisco, California, 94115, United States

Location

Pfizer Investigational Site

San Francisco, California, 94121, United States

Location

Pfizer Investigational Site

Washington D.C., District of Columbia, 20010, United States

Location

Pfizer Investigational Site

Gainesville, Florida, 32610, United States

Location

Pfizer Investigational Site

Miami, Florida, 33136, United States

Location

Pfizer Investigational Site

Atlanta, Georgia, 30309, United States

Location

Pfizer Investigational Site

Louisville, Kentucky, 40202, United States

Location

Pfizer Investigational Site

Boston, Massachusetts, 02215, United States

Location

Pfizer Investigational Site

Worcester, Massachusetts, 01655, United States

Location

Pfizer Investigational Site

Detroit, Michigan, 48202, United States

Location

Pfizer Investigational Site

Plymouth, Minnesota, 55446, United States

Location

Pfizer Investigational Site

Saint Paul, Minnesota, 55117, United States

Location

Pfizer Investigational Site

St Louis, Missouri, 63104, United States

Location

Pfizer Investigational Site

Albuquerque, New Mexico, 87131, United States

Location

Pfizer Investigational Site

New York, New York, 10021, United States

Location

Pfizer Investigational Site

New York, New York, 10032, United States

Location

Pfizer Investigational Site

The Bronx, New York, 10461, United States

Location

Pfizer Investigational Site

The Bronx, New York, 10468, United States

Location

Pfizer Investigational Site

Chapel Hill, North Carolina, 27599-7209, United States

Location

Pfizer Investigational Site

Durham, North Carolina, 27710, United States

Location

Pfizer Investigational Site

Cincinnati, Ohio, 45219, United States

Location

Pfizer Investigational Site

Cleveland, Ohio, 44195, United States

Location

Pfizer Investigational Site

Philadelphia, Pennsylvania, 19141, United States

Location

Pfizer Investigational Site

Houston, Texas, 77030, United States

Location

Pfizer Investigational Site

Annandale, Virginia, 22003, United States

Location

Pfizer Investigational Site

Fairfax, Virginia, 22031, United States

Location

Pfizer Investigational Site

Richmond, Virginia, 23249, United States

Location

Pfizer Investigational Site

Santurce, 00909, Puerto Rico

Location

Related Links

MeSH Terms

Conditions

Hepatitis C

Interventions

peginterferon alfa-2bRibavirinHCV 796

Condition Hierarchy (Ancestors)

Blood-Borne InfectionsCommunicable DiseasesInfectionsHepatitis, Viral, HumanVirus DiseasesFlaviviridae InfectionsRNA Virus InfectionsHepatitisLiver DiseasesDigestive System Diseases

Intervention Hierarchy (Ancestors)

RibonucleosidesNucleosidesNucleic Acids, Nucleotides, and Nucleosides

Study Officials

  • Pfizer CT.gov Call Center

    Pfizer

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 21, 2006

First Posted

August 23, 2006

Study Start

October 1, 2006

Primary Completion

July 1, 2008

Study Completion

July 1, 2008

Last Updated

February 11, 2013

Record last verified: 2013-02

Locations