NCT00366639

Brief Summary

The purpose of the ADHERE study is to develop a multi-center, observational, open-label registry of the management strategies of patients treated in the hospital for acute Heart Failure in the United States.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
24,118

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Oct 2001

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2001

Completed
4.3 years until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2006

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

August 18, 2006

Completed
3 days until next milestone

First Posted

Study publicly available on registry

August 21, 2006

Completed
Last Updated

November 2, 2009

Status Verified

October 1, 2009

First QC Date

August 18, 2006

Last Update Submit

October 29, 2009

Conditions

Heart Failure, CongestiveHeart Decompensation

Keywords

Heart failure, congestiveHeart decompensation

Outcome Measures

Primary Outcomes (1)

  • Course of care in the Emergency Department (ED) and course of care in the inpatient hospital, use of diuretics (increase urine excretion) vasodilators (relax artey and veins) and inotropeic agents (increase the function of the heart) rate of death

    From admission to discharge from the hospital

Secondary Outcomes (1)

  • Data from patient demographics ( sex, age, gender, race)

    at patients admission

Study Arms (1)

001

Other: Acute Decompensated Heart Failure

Interventions

Acute Decompensated Heart FailureOTHER

Treatment \& outcomes during hospital admission for Acute DHF

001

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

All consecutive adult patients admitted to an acute care hospital and treated actively for acute HF, where acute HF is defined clinically as a new onset with HF decompensation

You may qualify if:

  • Age greater than or equal to 18 years at the time of admission to the hospital
  • Received or is eligible to receive a principal hospital discharge diagnosis of HF
  • Decompensated HF is present as determined clinically by the patient care team

You may not qualify if:

  • HF is present as a co-morbid condition, but is not a principal focus of diagnosis or treatment during this hospitalization episode

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (7)

  • Kociol RD, Hammill BG, Fonarow GC, Klaskala W, Mills RM, Hernandez AF, Curtis LH. Generalizability and longitudinal outcomes of a national heart failure clinical registry: Comparison of Acute Decompensated Heart Failure National Registry (ADHERE) and non-ADHERE Medicare beneficiaries. Am Heart J. 2010 Nov;160(5):885-92. doi: 10.1016/j.ahj.2010.07.020.

    PMID: 21095276DERIVED

  • Maisel AS, Peacock WF, McMullin N, Jessie R, Fonarow GC, Wynne J, Mills RM. Timing of immunoreactive B-type natriuretic peptide levels and treatment delay in acute decompensated heart failure: an ADHERE (Acute Decompensated Heart Failure National Registry) analysis. J Am Coll Cardiol. 2008 Aug 12;52(7):534-40. doi: 10.1016/j.jacc.2008.05.010.

    PMID: 18687247DERIVED

  • Kamath SA, Drazner MH, Wynne J, Fonarow GC, Yancy CW. Characteristics and outcomes in African American patients with decompensated heart failure. Arch Intern Med. 2008 Jun 9;168(11):1152-8. doi: 10.1001/archinte.168.11.1152.

    PMID: 18541822DERIVED

  • Peacock WF 4th, De Marco T, Fonarow GC, Diercks D, Wynne J, Apple FS, Wu AH; ADHERE Investigators. Cardiac troponin and outcome in acute heart failure. N Engl J Med. 2008 May 15;358(20):2117-26. doi: 10.1056/NEJMoa0706824.

    PMID: 18480204DERIVED

  • Fonarow GC, Peacock WF, Horwich TB, Phillips CO, Givertz MM, Lopatin M, Wynne J; ADHERE Scientific Advisory Committee and Investigators. Usefulness of B-type natriuretic peptide and cardiac troponin levels to predict in-hospital mortality from ADHERE. Am J Cardiol. 2008 Jan 15;101(2):231-7. doi: 10.1016/j.amjcard.2007.07.066. Epub 2007 Dec 3.

    PMID: 18178412DERIVED

  • Hauptman PJ, Goodlin SJ, Lopatin M, Costanzo MR, Fonarow GC, Yancy CW. Characteristics of patients hospitalized with acute decompensated heart failure who are referred for hospice care. Arch Intern Med. 2007 Oct 8;167(18):1990-7. doi: 10.1001/archinte.167.18.1990.

    PMID: 17923600DERIVED

  • Fonarow GC, Peacock WF, Phillips CO, Givertz MM, Lopatin M; ADHERE Scientific Advisory Committee and Investigators. Admission B-type natriuretic peptide levels and in-hospital mortality in acute decompensated heart failure. J Am Coll Cardiol. 2007 May 15;49(19):1943-50. doi: 10.1016/j.jacc.2007.02.037. Epub 2007 Apr 30.

    PMID: 17498579DERIVED

MeSH Terms

Conditions

Heart Failure

Condition Hierarchy (Ancestors)

Heart DiseasesCardiovascular Diseases

Study Officials

  • Scios, Inc. Clinical Trial

    Scios, Inc.

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

August 18, 2006

First Posted

August 21, 2006

Study Start

October 1, 2001

Study Completion

February 1, 2006

Last Updated

November 2, 2009

Record last verified: 2009-10