Effects of Nerve Block on Knee Function After Knee Replacement

NCT00358241 | Withdrawn

• 1 other identifier: 04-03-05-05
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

Early physical therapy after knee surgery is very painful on top of pain from surgery. Pain following surgery can limit recovery. One way to treat pain is by giving intravenous (IV) pain medication with morphine. Another method is to use a "nerve block" which involves placing a thin catheter (tube) into the lower back near the nerves that sense pain in the knee and give a local anesthetic to numb the nerves. Sometimes both methods are used together. This research is being done to determine whether nerve blocks with a local anesthetic improve knee recovery in addition to providing pain relief as compared to IV pain medicine alone

Conditions

Postoperative Pain

Keywords

Nerve block, postoperative pain, analgesia

Interventions

Nerve block PROCEDURE

Eligibility Criteria

• Age: 21 Years - 80 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 21-80 year old
• ASA Physical Status ASA I and II
• Mentally competent
• Intellectually competent
• Body mass index \<35
• No severe cardiac diseases
• No severe pulmonary diseases
• Unilateral knee disease
• No other lower extremity joint disease
• No chronic narcotic therapy or illicit drug use

You may not qualify if:

• Age \<21 or \>80 year old
• ASA Physical Status \>ASA II
• Mentally incompetent
• Intellectually incompetent or cognitively impaired
• Non-English speaking patient
• Worker's compensation patient
• Body mass index \> 35
• Bilateral knee disease
• Has other lower extremity joint disease
• Severe cardiac diseases
• Severe pulmonary diseases
• Chronic narcotic therapy or illicit drug use
• Pregnancy

Sponsors & Collaborators

• Johns Hopkins University: lead

Study Sites (1)

Johns Hopkins Bayview Medical Center

Baltimore, Maryland, 21224, United States

Location

MeSH Terms

Conditions

Pain, Postoperative; Agnosia

Interventions

Nerve Block

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms; Perceptual Disorders; Neurobehavioral Manifestations; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Anesthesia, Conduction; Anesthesia; Anesthesia and Analgesia; Denervation; Neurosurgical Procedures; Surgical Procedures, Operative

Study Officials

• J Hang, MD, PhD

  Johns Hopkins Medicine, Johns Hopkins University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 27, 2006
• First Posted: July 31, 2006
• Last Updated: May 18, 2020

Record last verified: 2019-05

Locations

US (1)