Genetic Studies to Identify Stroke Subtypes and Outcome

NCT00357513 | Completed

• 2 other identifiers: 02022102-N-0221
• Study Type: observational
• Target: 840
• Locations: 1 country
• Sites: 3

Brief Summary

This study will characterize the gene response of the body's immune and inflammatory cells to stroke. There is a wide variation in stroke risk, stroke outcome, and response to clot-busting therapy for stroke. This variation may be due to differences in people's response to injury or infection, or to differences in genetic make-up between individuals. Genes store the biological information that determines the body's response to injury or infection. This study will analyze the activity of a large number of genes to try to learn which genes might be related to patient outcome. This, in turn, may lead to an understanding of which gene profiles are related to increased stroke risk and increased disability or death. Healthy volunteers over age 21 and stroke patients over age 21 who are admitted to the NIH Stroke Program at Suburban Hospital in Bethesda, Md., may be eligible for this study. Volunteers will be screened with a medical history, blood pressure and pulse measurements, electrocardiogram, and neurological examination. Participants will have 20 to 35 milliliters (about an ounce) of blood drawn for genetic studies. The genetic material will be extracted from the white blood cells and analyzed for normal and abnormal gene activity related to stroke. ...

Conditions

Cerebrovascular Disease; Stroke

Keywords

Cerebrovascular Disease; Gene Chip; Inflammation; Pathophysiology Stroke; Stroke Genomics; Stroke Subtypes; Neuroimaging; Clinical Outcome Measures; Stroke; CVA; Healthy Volunteer; HV; Normal Control

Eligibility Criteria

• Age: 21 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• HEALTHY VOLUNTEERS:
• Over age 21
• Healthy
• Willing to participate in the study
• Informed consent obtained
• ACUTE STROKE PATIENTS:
• Stroke patients admitted to Suburban or Holy Cross Hospitals
• Over age 21
• Willing to participate in the study
• Informed Consent obtained

You may not qualify if:

• HEALTHY VOLUNTEERS:
• Active medical problems
• Current symptomatic infection
• Current severe allergic disorders
• STROKE PATIENTS:
• Cardiovascular instability
• Severe anemia (hemoglobin less than 8.0 gm/dl)
• Hemorrhagic diathesis
• Current infection
• Current severe allergic disorders

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS): lead

Study Sites (3)

Suburban Hospital

Bethesda, Maryland, 20814, United States

Location

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Holy Cross Hospital, Silver Spring

Silver Spring, Maryland, 20902, United States

Location

Related Publications (3)

• Acierno JS Jr, Kennedy JC, Falardeau JL, Leyne M, Bromley MC, Colman MW, Sun M, Bove C, Ashworth LK, Chadwick LH, Schiripo T, Ma S, Goldin E, Schiffmann R, Slaugenhaupt SA. A physical and transcript map of the MCOLN1 gene region on human chromosome 19p13.3-p13.2. Genomics. 2001 Apr 15;73(2):203-10. doi: 10.1006/geno.2001.6526.

  PMID: 11318610 BACKGROUND

• Baird AE, Benfield A, Schlaug G, Siewert B, Lovblad KO, Edelman RR, Warach S. Enlargement of human cerebral ischemic lesion volumes measured by diffusion-weighted magnetic resonance imaging. Ann Neurol. 1997 May;41(5):581-9. doi: 10.1002/ana.410410506.

  PMID: 9153519 BACKGROUND

• Baird AE, Warach S. Magnetic resonance imaging of acute stroke. J Cereb Blood Flow Metab. 1998 Jun;18(6):583-609. doi: 10.1097/00004647-199806000-00001.

  PMID: 9626183 BACKGROUND

MeSH Terms

Conditions

Cerebrovascular Disorders; Stroke; Inflammation

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: July 26, 2006
• First Posted: July 27, 2006
• Study Start: June 3, 2002
• Study Completion: December 15, 2008
• Last Updated: July 2, 2017

Record last verified: 2008-12-15

Locations

US (3)