NCT00356395

Brief Summary

we hypothesized that combination therapy has additive beneficial effects to improve endothelial dysfunction and adipocytokine profiles in patients with hypertension.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
40

participants targeted

Target at below P25 for phase_4 hypertension

Timeline
Completed

Started Aug 2003

Typical duration for phase_4 hypertension

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2003

Completed
2.6 years until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2006

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

July 25, 2006

Completed
1 day until next milestone

First Posted

Study publicly available on registry

July 26, 2006

Completed
Last Updated

July 26, 2006

Status Verified

March 1, 2006

First QC Date

July 25, 2006

Last Update Submit

July 25, 2006

Conditions

Hypertension

Keywords

endothelial function, insulin resistance, adipocytokines

Outcome Measures

Primary Outcomes (1)

  • comparison of endothelium-dependent dilation among the 3 treatment schemes

Interventions

ramipril, candesartanDRUG

Eligibility Criteria

Age35 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • patients with mild to moderate hypertension

You may not qualify if:

  • We will exclude patients with severe hypertension, unstable angina, acute myocardial infarction, or renal insufficiency.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

HypertensionInsulin Resistance

Interventions

Ramiprilcandesartan

Condition Hierarchy (Ancestors)

Vascular DiseasesCardiovascular DiseasesHyperinsulinismGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Heterocyclic Compounds, 2-RingHeterocyclic Compounds, Fused-RingHeterocyclic Compounds

Study Officials

  • Kwang K Koh, MD

    Cardiology, Gil Heart Center, Gachon Medical School

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
DOUBLE
Purpose
TREATMENT
Intervention Model
CROSSOVER
Sponsor Type
OTHER

Study Record Dates

First Submitted

July 25, 2006

First Posted

July 26, 2006

Study Start

August 1, 2003

Study Completion

March 1, 2006

Last Updated

July 26, 2006

Record last verified: 2006-03