Maximizing the Efficacy of Cognitive Behavior Therapy and Contingency Management

NCT00350649 | Completed Phase 2 DMC

• 1 other identifier: 0407026913
• Study Type: interventional
• Target: 205
• Locations: 1 country
• Sites: 1

Brief Summary

Cognitive-behavioral coping skills therapy (CBT) is a widely used and recognized treatment that has been empirically validated for a range of substance use disorders, often with emergent effects and continuing improvement even after treatment ends. Treatment retention and compliance are associated with enhanced treatment outcomes in CBT. Contingency management (CM) also has very strong support and is associated with rapid, robust effects on targeted outcomes. Despite their many strengths, neither CBT nor CM is universally effective. It is now essential to seek strategies to maximize and extend the effectiveness of these two approaches and to better understand how these treatments exert their effects.

Conditions

Marijuana Dependence

Keywords

behavior modification; cognitive behavioral therapy; combination therapy; drug abuse therapy; drug addition; human therapy evaluation; psychotherapy; clinical trial phase II; coping; drug and alcohol abstinence; longitudinal human study; outcomes research; outpatient care; psychological reinforcement; therapy compliance; behavior and social research tag; human subjects; neuropsychological test; patient oriented research

Outcome Measures

Primary Outcomes (1)

• Self reported marijuana use (days of abstinence by week) and results of urine toxicology screens

  12 weeks

Secondary Outcomes (1)

• Economic analysis with use of PACC-SAT

  12 weeks

Study Arms (4)

1

EXPERIMENTAL

manualized delivery of CBT by trained clinicians

Behavioral: Standard CBT

2

ACTIVE COMPARATOR

CBT with Contingency Management reinforcement for attendance and completing homework (CBT+CM/adherence)

Behavioral: CBT+CM/adherence

3

EXPERIMENTAL

Contingency Management for abstinence alone (CM/abstinence)

Behavioral: CM/abstinence

4

ACTIVE COMPARATOR

Contingency Management integrated with CBT (CM/abstinence+CBT)

Behavioral: CM/abstinence+CBT

Interventions

Standard CBT BEHAVIORAL

Manualized delivery of CBT by trained clinicians

1

CBT+CM/adherence BEHAVIORAL

CBT and Clinical Management for attendance and completing homework

2

CM/abstinence BEHAVIORAL

Contingency Management

3

CM/abstinence+CBT BEHAVIORAL

Contingency Management for abstinence in addition to manualized CBT delivered by a trained clinician

4

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• year old marijuana dependent
• willing to sign consent
• no use of prescribed psychotropic drugs
• willing to give three individuals as contacts
• willing to accept randomization
• read and write English (third grade level)

You may not qualify if:

• unable to commit to 1 year follow up

Sponsors & Collaborators

• Yale University: lead
• National Institute on Drug Abuse (NIDA): collaborator

Study Sites (1)

ASAP/1 Long Wharf

New Haven, Connecticut, 06512, United States

Location

MeSH Terms

Conditions

Marijuana Abuse; Alcohol Abstinence; Patient Compliance; Behavior

Condition Hierarchy (Ancestors)

Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders; Drinking Behavior; Patient Acceptance of Health Care; Treatment Adherence and Compliance; Health Behavior

Study Officials

• Kathleen Carroll, PhD

  Yale University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 7, 2006
• First Posted: July 11, 2006
• Study Start: December 1, 2004
• Primary Completion: September 1, 2010
• Study Completion: September 1, 2010
• Last Updated: September 27, 2011

Record last verified: 2011-09

Locations

US (1)