Spatial Neglect and Bias in Near and Far Space

NCT00350012 | Unknown DMC

• 2 other identifiers: K02NS0470095K02NS047099
• Study Type: observational
• Target: 950
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this research study is to learn how people distribute their visual attention when looking at objects nearby versus far away, and why vision may become distracted at near versus far distances.

Conditions

Stroke

Keywords

stroke; visual; spatial neglect

Outcome Measures

Primary Outcomes (1)

• Kessler Foundation Neglect Assessment Process

  a performance based and behavioral measure for spatial neglect that utilizes and standardizes the administration of the Catherine Bergego Scale (CBS)

  From 1 or 2 sessions totaling approximately 2 hours to multiple sessions in one year

Secondary Outcomes (2)

• Behavior Inattention Test Behavior Inattention Test

  2 weeks

• Barthel Index

  2 weeks

Study Arms (2)

1

Persons who have had a stroke and either have, or do not have, a pathological asymmetry of perception, attention and action causing functional disability (spatial neglect; Barrett and Burkholder, 2006).

2

Healthy age- and education-matched volunteers

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Persons who have had a stroke. Also, healthy volunteers.

You may qualify if:

• The subject has a history of stroke.
• The subject is 18 to 100 years old.
• The subject is able to give Informed consent.
• The subject is post-Stroke with left-hemisphere injury and has no spatial neglect (no attentional imbalance).
• The subject is post-stroke with right hemisphere damage and has spatial neglect (attentional imbalance).
• Healthy subject with no brain injury.
• The subject is post stroke and has hemianopia (a "visual field cut").
• The subject is able and willing to comply with the study protocol, including availability for all scheduled clinic visits.

You may not qualify if:

• Subjects with brain tumors, head injury with loss of consciousness, visual disorders other than corrected near or far-sightedness, history of learning disabilities, dementia or Alzheimer's Disease.

Sponsors & Collaborators

• Kessler Foundation: lead
• National Institute of Neurological Disorders and Stroke (NINDS): collaborator

Study Sites (1)

Kessler Foundation, 1199 Pleasant Valley Way

West Orange, New Jersey, 07052, United States

Location

Related Publications (2)

• Boukrina O, Chen P, Budinoska T, Barrett AM. Exploratory examination of lexical and neuroanatomic correlates of neglect dyslexia. Neuropsychology. 2020 May;34(4):404-419. doi: 10.1037/neu0000619. Epub 2020 Jan 30.

  PMID: 31999167 DERIVED

• Caulfield MD, Chen P, Barry MM, Barrett AM. Which perseverative behaviors are symptoms of spatial neglect? Brain Cogn. 2017 Apr;113:93-101. doi: 10.1016/j.bandc.2016.11.002. Epub 2017 Feb 3.

  PMID: 28167411 DERIVED

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• A. M. Barrett, MD

  Stroke Rehabilitation Research, Kessler Foundation Research Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director, Stroke Research

Study Record Dates

• First Submitted: July 6, 2006
• First Posted: July 10, 2006
• Study Start: May 1, 2004
• Primary Completion: October 1, 2021
• Study Completion: October 1, 2021
• Last Updated: February 17, 2021

Record last verified: 2021-02

Locations

US (1)