Ocular Surface Changes in Patients With Cystic Fibrosis

NCT00345280 | Unknown

• 2 other identifiers: 8789N40605131/1894
• Study Type: observational
• Target: 26
• Locations: 1 country
• Sites: 1

Brief Summary

Cystic fibrosis(CF) is an inherited disease affecting children, adolescents and young adults with dysfunction of secretory glands.It is caused by mutations in the protein-coding gene which function as the cystic fibrosis transmembrane regulator (CFTR), responsible for the secretion of chloride ions in epithelial cells, adenocytes, sweat gland cells, pancreatic ducts,alimentary and respiratory tracts and eye. Assessment of the relationship between the inflammatory processes and apoptosis in the eye in the course of cystic fibrosis will allow determination of immunological exponents which may facilitate diagnosis.

Conditions

Eye Manifestations

Keywords

Cystic fibrosis; eye; inflammation; apoptosis; C11+

Interventions

impression cytology, obtain the tear fluid PROCEDURE

Vitamin A

Also known as: Becton Dickinson

Eligibility Criteria

• Age: 3 Years - 25 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

26 male and female patients aged 3-25 with clinically definite diagnosis of cystic fibrosis

You may qualify if:

• male and female patients aged 3-25 with clinically definite diagnosis of cystic fibrosis
• all patients must give written consent for participation in the study at screening

You may not qualify if:

• patients with a history of chronic disease of the immune system
• patients with the history of systemic diseases
• patients with the history chronic ocular diseases
• patients who have been treated with corticosteroids in the past 3 months prior to the screening visit

Sponsors & Collaborators

• University of Bialystok: lead

Study Sites (1)

Medical University

Bialystok, 15- 089, Poland

RECRUITING

MeSH Terms

Conditions

Eye Manifestations; Cystic Fibrosis; Inflammation; Lipodystrophy, Congenital Generalized

Condition Hierarchy (Ancestors)

Eye Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Pancreatic Diseases; Digestive System Diseases; Lung Diseases; Respiratory Tract Diseases; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Infant, Newborn, Diseases; Pathologic Processes; Lipid Metabolism, Inborn Errors; Metabolism, Inborn Errors; Lipodystrophy; Skin Diseases, Metabolic; Skin Diseases; Skin and Connective Tissue Diseases; Lipid Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Malgorzata Mrugacz, MD, PhD

  Department of Pediatric Ophthalmology Medical University of Bialystok, Poland

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Michal Sewerynski, Prof.

CONTACT

+48 22 6281944; minister@mnisw.gov.pl

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV

Study Record Dates

• First Submitted: June 27, 2006
• First Posted: June 28, 2006
• Study Start: August 1, 2006
• Study Completion: September 1, 2008
• Last Updated: June 17, 2008

Record last verified: 2008-06

Locations

PL (1)