An Epidemiological Study of Genetic Risk Factors for Prostate Cancer in African-American and Caucasian Males

NCT00342771 | Completed

• 2 other identifiers: 99990502105-C-N021
• Study Type: observational
• Target: 2,033
• Locations: 1 country
• Sites: 2

Brief Summary

This study will examine the association of genetic variants and gene expression patterns with the risk of prostate cancer. There will be (It will include?) genotype analysis of blood DNA from 600 patients with the disease and from 600 healthy people, and there will be a gene expression analysis of prostate tumors. Prostate cancer is a leading cause of death among men in Western countries. It is estimated that 220,000 or more new cases of the disease will occur in the United States during 2004. The disease incidence is rising. About 25% to 30% of the cancers become aggressive. The nonhereditary disease rarely occurs in men who are younger than age 40. There are large differences in incidence by geography and race. The highest rates are seen among African-American men in the United States. Also, although Caucasians have a lower rate of disease incidence and mortality in the United States, the rates among them are high compared with rates in some European countries. The reasons for such differences are not well understood, but both environmental and genetic risk factors are thought to be involved. Patients ages 40 to 80 years who have had prostate cancer confirmed within the past 6 months, who reside in Baltimore City or adjacent metropolitan counties, and who were born in the United States may be eligible for this study. They will be recruited in collaboration with the Departments of Pathology and Urology at the University of Maryland and the Baltimore Veterans Affairs Medical Center. Those men serving as controls in this study will be identified through the Department of Motor Vehicles database and will be matched by age and race with the patients who have cancer. The study will include 600 participants with prostate cancer and 600 participants in the control group. Trained interviewers will administer two questionnaires. The primary questionnaire will be used to assess information such as medical and cancer history, tobacco use, current medications, occupational history, family medical history, and socioeconomic status. A supplemental questionnaire will pertain to patients' exposure to risk factors for prostate cancer. It will assess the human body, diet, medical history, family medical history, and sexual history. The section on sexual history will be self-administered. Patients will undergo collection of blood and urine for various tests. For cancer patients with prostate surgery, there will also be a collection of tissue, to be performed at the time that the prostate gland is scheduled for surgical removal. The pattern of gene expression will be analyzed in low- and high-stage tumors. There will be no direct benefit from participating in the study, but participants will receive an incentive of up to $75 to participate in the study. No form of treatment is involved in this study. However, it is hoped that the study findings will improve researchers' understanding of prostate cancer biology with respect to the causes of the health variances between African-Americans and Caucasians. ...

Conditions

Prostate Cancer

Keywords

Tobacco Use; Tumor Biology; Biomarker; Risk Factor; Health Disparity

Outcome Measures

Primary Outcomes (2)

• Identification of risk factors

  association of tobacco use, obesity, inflammation and anti- inflammatory drugs, sexual activity and sexually transmitted diseases, and ancestral markers with prostate cancer and lethal disease

  After completion of recruitment

• Identification of disease biomarkers

  association of blood and/or urine-based metabolites, and blood-based immune- inflammation markers with either ancestry, lifestyle factors, prostate cancer, and lethal disease.

  Ongoing

Study Arms (2)

NCI Maryland pop-based controls

population-based controls

NCI-Maryland Prostate Cancer Cases

prostate cancer cases

Eligibility Criteria

• Age: 40 Years - 90 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study is a case-control study with a clinical and a community component. Participants are African- American and Caucasian males who resided in Baltimore city and surrounding areas. The cases were recruited at two Baltimore hospitals, the Veterans Affairs Medical Center and the University of Maryland Medical Center. Cases had pathologically confirmed prostate cancer. The population-based controls were identified through the Maryland Department of Motor Vehicle database.@@@@@@

* ELIGIBILITY CRITERIA CASE SUBJECT SELECTION We will recruit incident cases of pathologically confirmed PCa at all stages of the disease that are age 40 to 90 years. Treatment can be surgery or therapy. The following check list will be used to verify eligibility of a case subject. ELIGIBILITY CHECK LIST - PROSTATE CANCER CASES CRITERIA (ALL MUST BE CHECKED): * Has been diagnosed with prostate cancer within the last two years * Pathological diagnosis of prostate cancer made at the local hospital pathology department * Resides in Baltimore City or contiguous metropolitan counties, Anne Arundel and Prince George s counties, Eastern Shore, western and northern Maryland, or adjacent counties in Pennsylvania, Delaware, Virginia, or the Washington Metropolitan area * Has a residential working phone within his home * Born in the United States * Of African-American or Caucasian descent, and age 40 to 90 years * A non-objection statement by the physician from the hospital where the patient was identified, or listed as the treating physician by the tumor registry or surgical pathology report, to contact the patient * Is not currently residing in an institution, such as a prison, nursing home, or shelter * Is not a severely ill patient in the intensive care unit * Speaks English well enough to be interviewed * Is able to give informed consent * Is physically and mentally capable of performing the interview * Has never been interviewed as a control for this study * Subject provides informed consent and signs form. Unwilling Unavailable SELECTION OF POPULATION-BASED CONTROLS Population-based controls will be identified through the Department of Motor Vehicles (DMV), and matched on age (5-year intervals), gender and race to cases. Recruitment of controls will start concurrently with case accrual, using the age and race frequency distribution of cancer patients in previous years, but recruitment objectives can be re-assessed to ensure a frequency-matched study. We will exclude controls that do not have a listed home phone number. The following check list will be used to verify eligibility of a control subject. ELIGIBILITY CHECK LIST - POPULATION-BASED CONTROLS CRITERIA (ALL MUST BE CHECKED): * Resides in Baltimore City or contiguous metropolitan counties, Anne Arundel and Prince George s counties, Eastern Shore, western and northern Maryland, or adjacent counties in Pennsylvania, Delaware, Virginia, or the Washington Metropolitan area * Has a residential working phone within his home * Born in the United States * Of African-American or Caucasian descent, and age 40 to 90 years * Does not have a personal history of cancer other than basal and non-melanomic skin cancer * Have never had radiation therapy or chemotherapy Is not currently residing in an institution, such as a prison, nursing home, or shelter * Speaks English well enough to be interviewed * Is able to give informed consent * Is physically and mentally capable of performing the interview * Has never been interviewed as a control for the study * Subject provides informed consent and signs form. Unwilling Unavailable

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Cancer Institute (NCI): lead

Study Sites (2)

University of Maryland Medical Center

Baltimore, Maryland, 21201-1595, United States

Location

VA Hospital, Baltimore

Baltimore, Maryland, United States

Location

Related Publications (3)

• DeMarzo AM, Nelson WG, Isaacs WB, Epstein JI. Pathological and molecular aspects of prostate cancer. Lancet. 2003 Mar 15;361(9361):955-64. doi: 10.1016/S0140-6736(03)12779-1.

  PMID: 12648986 BACKGROUND

• Roberts WW, Platz EA, Walsh PC. Association of cigarette smoking with extraprostatic prostate cancer in young men. J Urol. 2003 Feb;169(2):512-6; discussion 516. doi: 10.1097/01.ju.0000046160.80804.7f.

  PMID: 12544299 BACKGROUND

• Hoffman RM, Gilliland FD, Eley JW, Harlan LC, Stephenson RA, Stanford JL, Albertson PC, Hamilton AS, Hunt WC, Potosky AL. Racial and ethnic differences in advanced-stage prostate cancer: the Prostate Cancer Outcomes Study. J Natl Cancer Inst. 2001 Mar 7;93(5):388-95. doi: 10.1093/jnci/93.5.388.

  PMID: 11238701 BACKGROUND

MeSH Terms

Conditions

Prostatic Neoplasms; Tobacco Use

Condition Hierarchy (Ancestors)

Genital Neoplasms, Male; Urogenital Neoplasms; Neoplasms by Site; Neoplasms; Genital Diseases, Male; Genital Diseases; Urogenital Diseases; Prostatic Diseases; Male Urogenital Diseases; Behavior

Study Officials

• Stefan Ambs, Ph.D.

  National Cancer Institute (NCI)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 19, 2006
• First Posted: June 21, 2006
• Study Start: November 8, 2004
• Primary Completion: August 6, 2020
• Study Completion: August 6, 2020
• Last Updated: August 14, 2020

Record last verified: 2020-08

Locations

US (2)