Fungicide Exposure Assessment Among Apple and Peach Farmers in the Argicultural Health Study

NCT00342394 | Completed

• 2 other identifiers: 99990204902-C-N049
• Study Type: observational
• Target: 75
• Locations: 1 country
• Sites: 1

Brief Summary

This protocol describes an exposure assessment study of farmers in North Carolina and Iowa who personally apply the fungicides captan, thiophanate-methyl, and benomyl to apple and peach orchards. The exposure assessment will include environmental measurements as well as biological monitoring data. The biomonitoring data will be based on 24-hour urinary metabolites of the three fungicides selected for study. The study is being done in collaboration with the Argicultural Health Study (AHS), a large prospective health study of licensed private (farmer) and commercial applicators, and the spouses of private applicators. The AHS is sponsored by the National Cancer Institute, the National Institute of Environmental Health Sciences and the Environmental Protection Agency. The study described here will be conducted by the National Institute of Occupational Safety and Health. In summary, the objectives of this study are 1) to measure actual exposures to the target fungicides using both environmental and biological measures of exposure, 2) to identify and quantify major determinants of exposure, 3) to describe within- and between-worker exposure variability, and 4) to evaluate, to the extent possible, agreement between exposure estimates computed using the AHS exposure algorithms and exposure estimates based on actual measurements.

Conditions

Pesticides; Occupational Exposure

Keywords

Biological Monitoring; Exposure Determinants; Exposure Validation; Occupational Exposure; Pesticides; Agriculture

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Participants will be recruited from a sub-sample of the AHS cohort.
• To be eligible for this study, AHS participants must:
• Currently grow apples or peaches and,
• Plan to personally apply captan during the spring/summer growing season.

Sponsors & Collaborators

• National Cancer Institute (NCI): lead
• Centers for Disease Control and Prevention: collaborator
• National Institute for Occupational Safety and Health (NIOSH/CDC): collaborator

Study Sites (1)

National Institute for Occupational Safety and Health

Atlanta, Georgia, United States

Location

Related Publications (3)

• Carter SD, Laskey JW. Effect of benomyl on reproduction in the male rat. Toxicol Lett. 1982 Apr;11(1-2):87-94. doi: 10.1016/0378-4274(82)90111-4.

  PMID: 7090021 BACKGROUND

• Brouwer DH, Brouwer R, De Mik G, Maas CL, van Hemmen JJ. Pesticides in the cultivation of carnations in greenhouses: Part I--Exposure and concomitant health risk. Am Ind Hyg Assoc J. 1992 Sep;53(9):575-81. doi: 10.1080/15298669291360175.

  PMID: 1524032 BACKGROUND

• Barnes TB, Verlangieri AJ, Wilson MC. Reproductive toxicity of methyl-1-(butylcarbamoyl)-2-benzimidazole carbamate (benomyl) in male Wistar rats. Toxicology. 1983 Sep;28(1-2):103-15. doi: 10.1016/0300-483x(83)90110-5.

  PMID: 6636195 BACKGROUND

Study Officials

• Michael Alavanja, Ph.D.

  National Cancer Institute (NCI)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: June 19, 2006
• First Posted: June 21, 2006
• Study Start: November 14, 2001
• Study Completion: May 1, 2013
• Last Updated: April 5, 2018

Record last verified: 2013-05-01

Locations

US (1)